We are looking for a highly motivated research technician or lab manager who wants to contribute to cutting-edge biomedical research with a focus on epigenetics, cancer, and whole genome medicine. Our lab is based at the CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences in Vienna. It combines advanced technology (single-cell sequencing, drug screening, mass spectrometry, machine learning, etc.) with relevant biological models and access to patients.
We are looking for highly motivated, well-organized, and hard-working candidates who feel comfortable working in a highly dynamic and ambitious research environment. A typical candidate would have a Bachelor or Master degree in the life sciences and prior experience doing wet-lab work in a demanding environment. Candidates with a TA/MTA diploma or with a PhD will also be considered. Tasks and pay are commensurable with experience and skills. We take career development of our staff seriously at CeMM. For example, we will train the successful candidate in various state-of-the-art technologies that are in high demand in both academia and industry, and we encourage substantial contribution and co-authorship for publications in top journals. We also expect to fill the more senior position of a lab manager within the next few years, thus providing the potential for career development within CeMM depending on interest and performance.
- Next generation sequencing. Preparing samples for genome, epigenome, and transcriptome mapping
- Cell culture. Maintaining and manipulating cell lines and primary cells for biomedical research
- Gene targeting. Using CRISPR technology to create knockout cell lines
- Drug screening. Conducting epigenetic drug screens in collaboration with the chemical biology platform at CeMM
- Technology development. Working together with PhD students or postdocs to develop innovative epigenome technologies
- Lab management. Keeping track of lab resources and contributing to order management
- Training. Helping new staff and junior lab members to get started in the lab
The Lab (http://www.medical-epigenomics.org/)
The Medical Epigenomics Lab at CeMM combines large-scale epigenome analysis with stem cell biology and computational modeling, in order to better understand and treat cancer and other diseases. We focus broadly on the blood as the organ that connects all other organs, and we work closely with biologists and medical researchers at the Medical University of Vienna, aiming to advance personalized medicine through epigenome sequencing and bioinformatic innovation. Specific research interests include (but are not limited to):
- Epigenomics. We perform large-scale epigenome mapping in order to dissect the dynamics of cancer development and emerging drug resistance. This work is closely connected with the BLUEPRINT project and the International Human Epigenome Consortium.
- Technology. Exciting biomedical research is often driven by new technologies. Our lab is therefore heavily invested into technology development, including single-cell protocols, nanopore sequencing, CRISPR, and epigenome editing.
- Bioinformatics. New algorithms and advanced computational methods allow us to accurately infer epigenetic cell states from large-scale datasets, in order to reconstruct the epigenetic landscape that controls cellular differentiation and reprogramming.
- Diagnostics. Using large-scale DNA methylation mapping, bioinformatic prioritization, and functional characterization, we strive to develop clinically relevant biomarkers for informing personalized cancer therapy.
The Principal Investigator (http://christoph-bock.org/)
Christoph Bock is an epigenome researcher and principal investigator at the CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences. He is also a guest professor at the Medical University of Vienna's Department for Laboratory Medicine, the scientific coordinator of the Bio-medical Sequencing Facility at CeMM, and an adjunct group leader at the Max Planck Institute for Informatics in Germany. He has a background in bioinformatics and epigenomics (http://scholar.google.com/citations?user=9qSsTcIAAAAJ), with a PhD at the Max Planck Institute for Informatics (for which he received an Otto Hahn Medal by the Max Planck Society) and postdoctoral re-search at the Broad Institute and Harvard University (where he contributed to the Roadmap Epigenomics Project). Christoph joined CeMM in 2012, and he is a 2014 recipient of the New Frontier Group award of the Austrian Academy of Sciences. He leads Genom Austria (http://www.personalgenomes.org/austria), which is the Austrian Personal Genome Project; and he is a principal investigator in several EU projects, most notably for BLUEPRINT, which is the European contribution to the International Human Epigenome Consortium.