Fred Hutchinson Cancer Research Center, home of three Nobel laureates, is an independent, nonprofit research institution dedicated to the development and advancement of biomedical research to eliminate cancer and other potentially fatal diseases.
Recognized internationally for its pioneering work in bone-marrow transplantation, the Center's five scientific divisions collaborate to form a unique environment for conducting basic and applied science. The Hutchinson Center, in collaboration with its clinical and research partners, the University of Washington and Seattle Children's, is the only National Cancer Institute-designated comprehensive cancer center in the Pacific Northwest.
A qualified and motivated candidate is sought to join the Optides Program (Project Violet) at Fred Hutch. Our program is focused on the discovery and advancement of new treatments for pediatric brain cancers and other devastating diseases. Building on the success of Tumor Paint, we have developed a novel way of making knottin peptides, giving us unique access to the mid-sized medicine space. We are looking for a technician to join our growing team to help with chemical modification of these peptides for the design and synthesis of peptide-drug conjugates (PDCs).
The responsibilities and duties expected of this position are to support all aspects of the synthesis, purification and characterization of novel Peptide Drug Conjugates (PDC's). This includes the ability to conjugate fluorescent dyes and labels to peptides using standard chemical methods and using various organic chemical techniques to attach bifunctional linkers to drugs. The candidate will be expected to have a level of comfort working with chemotherapeutic and radioactive reagents. This position will require meticulous organizational skills and attention to detail as the group is now adopting high-throughput techniques, with programs across many disease areas.
Other responsibilities will include peptide and organic molecule purification using reversed-phase, normal-phase, and size-exclusion chromatography. Applicants are expected to be able to research and execute methods found in the literature, have the ability to scale these methods when appropriate, and to organize their data into reports that are used downstream in the drug discovery process with minimal supervision. Candidates with previous peptide conjugation and medicinal chemistry experience will be strongly considered.
The ideal candidate for this position is a research technician with a BS or MS in Chemistry or Biochemistry and 1-2 years of technical lab experience in an academic or industry setting. The position requires a high level of organization and the ability to manage multiple projects at once. The candidate must be skilled in basic organic transformations, and associated purification techniques. Experience in cloning, cell culture, protein expression and purification is highly desired. The candidate must have a proven ability to manage independent research and to meet deadlines in addition to good written and oral communication skills.
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