Research Scientist/Engineer 2

University of Washington - Genomce Sciences Department
Job Location
Seattle, WA
Job Description

The GS Department has an outstanding opportunity for a Research Scientist/Engineer 2 (RSE 2). The RSE2 will execute laboratory projects directly and provide experimental support for projects investigating the role of genomic structural variation in human disease and primate evolution for the Principal Investigator (PI), postdoctoral fellows, and graduate students. This lab is involved in several different projects simultaneously. Techniques used will include DNA sequencing, genomic clone characterization, and gene/protein characterization.

This position will work in a prominent laboratory whose work impacts other researchers worldwide. High functionality will be reflected in even greater funding opportunities and enhancement of the reputation of the University as a biomedical research powerhouse.

Core responsibilities include the following:
• Design experiments using novel and innovative methods and examine proposals to determine the projects and methodologies best suited to the research objectives. The RSE 2 may seek guidance as needed from the Principal Investigator and Senior Fellows in the lab.
• Independently perform intricate scientific procedures and operate complex scientific equipment, including HiSeq 2000, 2500, NextSeq 500, MiSeq and PacBio RSII.
• Independently perform standard molecular biology techniques, including array comparative genomic hybridization (aCGH), cloning, PCR, and DNA and RNA isolation.
• Use DNA sequence analysis software applications to assemble, manipulate, format and/or perform statistical analyses of data.
• Independently prepare and present written and oral reports of experimental results.
• Write and edit manuscripts; to include: assembly, organization, analysis and interpretation of data.
• Train and direct the work of other laboratory personnel with respect to proper laboratory techniques, the use of laboratory equipment, and safety procedures.
• May direct the operation of one or more facets of the research laboratory.
• May evaluate and assist in the selection of new equipment and laboratory procedures.
• Perform the duties of Research Technician II as required.


Bachelor of Science degree in Biology, Genetics, Genomics, or other relevant biological science AND three or more years of related research experience

• Experience with next-generation sequencing technologies.
• Experience and knowledge of the fundamental concepts, practices and procedures required for working in a genome laboratory.
• Able to work independently and as part of a multidisciplinary team
• Willing to learn and apply new techniques.
• Self-motivated with the ability to take initiative and work independently.
• Excellent communication skills.
• Exact attention to procedural detail.
• Meticulous record-keeping skills.
• Strong organizational abilities.
• Able to organize and work with large numbers of samples.
• Must have basic computational skills to store, analyze, and present data using Microsoft Word, Excel, and PowerPoint.

• Significant knowledge in next-generation sequencing and molecular inversion probe technology.
• Able to critically review information related to autism pathogenic variation. Understands new concepts with minimal assistance.
• Ability to develop novel or innovative sequencing techniques to understand complex regions of the human genome.
• Ability to review goals, analyze processes necessary to achieve those goals, and develop techniques and systems required to meet those goals. Often explores new areas and seeks opportunities to apply new knowledge to work.
• Write and prepare research project reports to be presented during scientific meetings. The PI and/or senior level researchers may review manuscript drafts written by the RSE2 providing feedback as needed.

Equivalent education/experience will substitute for all minimum qualifications except where there are legal requirements such as license/certification/registration.

• Master’s degree in Microbiology, Genetics or related Life Sciences field
• PCR & qPCR for genotyping
• DNA & RNA isolation
• Expertise in ABI fluorescent and next-generation sequencing
• Cell line maintenance
• Background in sequence analysis and phylogenetics
• Experience in team-focused work environment

About Our Organization

The University of Washington (UW) is proud to be one of the nation’s premier educational and research institutions. Our people are the most important asset in our pursuit of achieving excellence in education, research, and community service. Our staff not only enjoys outstanding benefits and professional growth opportunities, but also an environment noted for diversity, community involvement, intellectual excitement, artistic pursuits, and natural beauty.

The Department of Genome Sciences (GS) is part of the University of Washington School of Medicine (UW SoM) and is comprised of 27 labs addressing leading edge questions in biology and medicine by developing and applying genetic, genomic and computational approaches taking advantage of genomic information now available for a host of species. GS is making major contributions in the application of genome science to understand the fundamentals of biology and to improve human health and well-being.

Genome Sciences is a collaborative department supported by very different academic disciplines. We work with a multitude of Program Investigators (PIs) in departments both on the UW campus as well as worldwide. The department has gone through significant expansion since its beginning in 2001 with annual grant awards of $41.5M in FY12. The department has 47 training, teaching, and research faculty.

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