Research Scientist I

Broad Institute
Job Location
Cambridge, MA
Job Description

The Proteomics Platform at the Broad Institute is seeking a Research Scientist to lead large scale efforts in the execution of targeted proteomic signature profiling assays. Under the auspices of the LINCS program (, we have developed mass spectrometry-based assays that monitor the levels of important sentinel phosphorylation sites and histone post-translational modifications in biological samples.

Over the next 5 years, we will engage in drug and genetic perturbational profiling of cellular systems in cancer, neurobiology, and other selected systems to generate an unprecedented amount of proteomic data. Some of these data will be collected using next-generation data-independent acquisition (DIA) techniques. Our goal is to formulate proteomic “connectivity maps” of gene and drug function that illuminate the cellular mechanisms and interrelations of signaling and epigenetics.

We are looking for a highly motivated scientist to guide these efforts and to engage in further collaborations that take advantage of our proteomic assays. This person will be responsible for managing the overall programmatic goals of the LINCS project, including coordination of a small team’s efforts. In doing so, they will have the opportunity to interact with a wide variety of colleagues with diverse scientific backgrounds including biochemists, chemists, bioinformaticians, and computational biologists. There will be extensive opportunities for publication and presentation of results at conferences as well as supervisorial opportunities.

Characteristic Duties Include:
- Planning and execution of proteomics experiments
- Development of novel proteomic assay panels
- Operation and troubleshooting of state-of-the art LCMS mass spectrometry systems
- Analysis and interpretation of mass spectrometry data, including “DIA” and targeted data
- Ensuring that data are of the highest quality
- Maintenance of metadata and records associated with sample generation and assay execution
- Coordination of a team of interdisciplinary scientists for project goals; project management
- Attending and/or leading meetings for setting operational and scientific priorities
- Contributing to joint presentations and NIH progress reports
- Interfacing with NIH staff and peers at other LINCS centers
- Attendance of and presentations at external conferences and consortium meetings
- Writing of scientific manuscripts and contributing to grant applications
- Engaging in and managing further collaborations using our core proteomic technologies
- Make recommendations to senior staff as to best practices and development of standard operating procedures

- The successful candidate will have a strong background in state-of-the-art proteomics and mass spectrometry.
- Experience with targeted proteomics is highly desirable.
- The candidate must also feel comfortable with large-scale data analysis and computational methodologies.
- Prior participation in or management of large-scale collaborative projects is a plus.
- Working knowledge of laboratory automation and modern molecular biology techniques will be helpful.
- Importantly, this person must interact extremely well with a wide variety of team members ranging from junior research associates to NIH program officers, so strong communication skills are key.

The candidate will likely hold a Ph.D. and relevant post-doctoral research experience in biochemistry, biology, or chemistry, although exceptions might be made for extraordinary candidates.

The Broad Institute will not offer visa sponsorship for this opportunity.

EOE/Minorities/Females/Protected Veterans/Disabilities

If interested, please apply online at

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