To contribute to the achievement of the School of Biosciences’ research vision in translational molecular toxicology by undertaking specified research activities within a thriving and well-established collaboration with a team of scientists at Unilever.
This post forms the central component of a research project with Unilever “Towards an integrated approach in defining the MoA / KE of chemicals”. As such the postholder will build upon some very large scale multi-omics studies (transcriptomics and metabolomics) that have recently investigated the effects of chemicals on the health of Daphnia magna, specifically with the goal to discover modes of action and putative key events. The postholder will focus on the translation of these putative key events into a robust mechanistic understanding of toxicity; and additionally to collaborate with scientists from Unilever to integrate this new knowledge into their chemical safety science. Significant opportunities exist to more deeply mine the wealth of omics data that has been generated within the earlier laboratory investigations. The role will be to conduct Daphnia toxicity exposure studies focusing on high resolution concentration-response studies, conducting targeted gene expression and metabolite assays, undertake extensive statistical analyses to build and characterise the key event relationships within an Adverse Outcome Pathway framework, and ultimately generate new knowledge in toxicology.