Research Associate II

Organization
Broad Institute
Job Location
Cambridge, MA
Job Description

The Broad Institute of MIT and Harvard is the world’s leading biomedical research institute dedicated to the bold mission of using the full power of genomics to transform the understanding and treatment of disease. The Broad Institute seeks to describe all of the molecular components of life and their connections; discover the molecular basis of major human diseases; develop effective new approaches to diagnostics and therapeutics; and disseminate discoveries, tools, methods, and data openly to the entire scientific community.

Founded in 2004 by Eric Lander and philanthropists Eli and Edythe L. Broad, the Broad Institute includes faculty, professional staff, and students from throughout the MIT and Harvard biomedical research communities and beyond, with collaborations spanning more than a hundred private and public institutions in more than 40 countries worldwide.

OVERALL RESPONSIBILITY
We are looking for a highly motivated individual, who has extensive experience in maintaining mammalian cell lines, primary neuronal cell culture and pluripotent stem cell culture, to work as part of a research team, aiming to characterize in depth the function of candidate risk genes associated with psychiatric disorders and the functional consequences of mutations of the genes. The candidate is expected to develop and apply a number of methods to generate and maintain multiple types of mammalian cell lines and tissue cultures for different projects, as well as pluripotent stem cell-derived neurons. Experience with basic techniques of molecular biology, immunochemistry (IHC) and/or biochemical assays is an advantage. Basic computer skills and previous laboratory experience are required.

The Stanley Center and the Broad Institute provide a vibrant research environment with close links to MIT, Harvard and the Harvard-affiliated hospitals across Boston. Being a member of our team will provide the opportunity for your contributions to be utilized and recognized across the vast global network of researchers in the fields of genomics and psychiatric disease research.

CHARACTERISTIC DUTIES
- Develop and apply multiple methods to routinely provide and maintain different types of primary mammalian (rodent) cell and tissue cultures, such as HEK293 cell culture, primary neuronal culture, or pluripotent stem cell-
derived neurons
- Ability to work in a flexible environment both independently and on multidiscipline project teams
- Interact and coordinate with collaborators as required

QUALIFICATIONS
- B.S. in biology, neurobiology, chemistry, molecular/cellular biology or a related field, with at least 2 years related cell culture experience
- Prior lab experience in maintaining mammalian (rodent) primary cell cultures and tissue cultures from a wide range of tissues (cortical, striatal, hippocampal)
- Comfortable working with automated liquid handling instruments for large-scale neuronal culture
- Outstanding personal initiative and communication skills, and be able to work in a team
- Must be comfortable working with animals
- Exceptional organizational and time management skills, lab notebook practices and attention to detail
- Must be able to use sound judgment to handle a variety of tasks and to shift priorities simultaneously, as well as to effectively solve problems

EOE/Minorities/Females/Protected Veterans/Disabilities

The Broad Institute will not offer visa sponsorship for this opportunity.

If interested, please apply online at http://track.tmpservice.com/ApplyClick.aspx?id=2192889-2647-7821

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