Research Associate I

Broad Institute
Job Location
Cambridge, MA
Job Description

The Broad Institute of MIT and Harvard is the world’s leading biomedical research institute dedicated to the bold mission of using the full power of genomics to transform the understanding and treatment of disease. The Broad Institute seeks to describe all of the molecular components of life and their connections; discover the molecular basis of major human diseases; develop effective new approaches to diagnostics and therapeutics; and disseminate discoveries, tools, methods, and data openly to the entire scientific community.

Founded in 2004 by Eric Lander and philanthropists Eli and Edythe L. Broad, the Broad Institute includes faculty, professional staff, and students from throughout the MIT and Harvard biomedical research communities and beyond, with collaborations spanning more than a hundred private and public institutions in more than 40 countries worldwide.

The Broad Institute of Harvard and MIT is looking for an exceptional candidate for a unique Research Associate position. This position affords the exciting opportunity to be part of a research effort at the Broad Institute aiming to delineate systemic cancer biology and discover novel therapeutic targets. The most prominent example of these systemic interactions is cachexia, the wasting syndrome associated with many cancers, which serves as a major focus of our work.

The candidate will assist in the development of cancer models from human cell lines that represent different cellular lineages, drug-resistant states, and cachexia-inducing phenotypes. He/she will test the model systems in immuno-compromised mice for their ability to form tumors. He/she will subsequently use these cancer model systems in a high-throughput manner to screen for novel mediators of cachexia and cancer cell dependencies. He/she will be part of a multi-disciplinary team that evaluates new technologies and approaches to discover and validate novel systemic cancer biology.

The candidate is expected to work largely independently on a daily basis after training, but will be closely mentored by a Research Scientist and others.The Broad Institute provides a vibrant research environment with close links to top academic institutions across the Boston Area and provides the potential for your contributions to be used and recognized worldwide.

- Learn and execute existing pipeline of in vitro bioassays, high dimensional phenotypic readouts, and animal protocols.
- Handles cell culture of sensitive primary human cells for high-throughput use. Uses established protocols and works closely with Broad platforms, facilities, and collaborators.
- Works with mouse models to assess tumor formation, cachectic phenotype, and drug response.
- Process animal samples for downstream molecular biology and IHC.
- Works with others to refine protocols and explore novel techniques to incorporate them into experimental and analytical pipeline.
- Operates and maintains laboratory equipment to complete investigations.
- Prepares, orders, and maintains stocks of necessary reagents, solutions and supplies.
- Documents, compiles, and analyzes experimental protocols and data.
- Attends team meetings to share results, plan projects and experiments.
- Other related tasks as required.

- Strong interpersonal, communication, and organizational skills, including the ability to handle a variety of tasks in a fast-paced environment, large complex experiments, and large data sets, all of which demand great attention to detail.
- Proactive in identifying problems and solutions to address them.
- Must be an exceptional team player.
- Must possess a high level of initiative and the ability to work independently.

- Bachelor degree in Biology or related field required. 0-2 yrs of experience working in a scientific research setting a plus.
- Familiarity of basic cell culture and molecular biology laboratory techniques, including recombinant DNA and protein biochemistry, strongly desired.
- Familiarity with fluorescent microscopy is desirable.
- Experience with immuno-compromised mice (injections, monitoring, surgery, etc.) will be advantageous.

The Broad Institute will not offer visa sponsorship for this opportunity.

EOE/Minorities/Females/Protected Veterans/Disabilities

To apply for this position, please CLICK HERE

About Our Organization

NIH's Michael Lauer looks at the number of grants, their amount, and funding success rates at the agency for last year.

At Nature, Johns Hopkins' Gundula Bosch describes her graduate program that aims to get doctoral students thinking about the big picture.

Patricia Fara writes about childcare funding, and women in science and science history at NPR.

National Institute of Environmental Health Sciences researchers have visualized the career paths of former postdocs.