Research Associate, Center for Genomics of Neurodegenerative Disease

Organization
New York Genome Center
Job Location
101 Avenue of the Americas
New York, NY 10013
Job Description

The CGND is looking for a well-organized, methodical, and highly motivated Research Associate. This is an exciting opportunity to become part of a dynamic group that is investigating the interactions between motor neurons and glial cells in ALS pathology using hiPSC cell-based models combined with next generation sequencing and CRISPR technology. Our particular focus is to examine the transcriptional, translational, and functional impact of causative ALS mutations in a cell type specific manner. The individual will interface with the Director and key scientific staff to assume responsibility for hiPSC culture, differentiation, functional assays, and RNA harvesting for NGS. The Research Associate will be part of an interdisciplinary team working in a fast-paced environment.

Responsibilities include, but are not limited to:

  • Conduct, design, and troubleshoot experiments, both independently and in collaboration with colleagues;
  • CRISPR-based genome editing and transcriptional perturbations of causative ALS genes;
  • Differentiation of hiPSCs into motor neurons and glial cells;
  • Consult with scientific literature and other scientists as needed to better understand scientific experiments and problems, and propose solutions to emerging problems;
  • Perform routine biochemical and molecular biology techniques (PCR, nucleic acid purification, qPCR, ELISA, Western blotting, etc.);
  • Record and communicate findings accurately and professionally.
Requirements
  • B.Sc. or M.Sc. in Cell Biology, Molecular Biology, Neuroscience, or related field with at least 1 year of relevant laboratory experience;
  • Mammalian cell culture experience required:
    • Standard cell culture support, including maintaining, freezing, and plating of cell lines;
    • Experience with the culture and/or differentiation of hiPSCs strongly desired
    • Experience with electroporation and/or transfection a plus;
    • Experience with 96-well format for cell culture a plus;
  • Significant understanding of neurobiology and neurodegenerative disease a plus;
  • Experience using Benchling or other electronic notebooks a plus;
  • Occasional weekend work as required by tissue culture responsibilities;
  • The ideal candidate will be proficient in at least oneof the following disciplines:
    • Molecular Biology - PCR, DNA/RNA purification, qPCR, restriction enzyme and Gibson-based cloning, DNA electrophoresis;
    • Biochemistry – SDS-PAGE, Western blotting, immunoprecipitation;
    • CRISPR – gene editing and/or transcription activation and repression; and
    • mESC, miPSC, hESC, or hiPSC differentiations - experience with neuronal or glial cell types a plus.
About Our Organization

The New York Genome Center (NYGC) is an independent, non-profit organization that leverages the collaborative resources of leading academic medical centers, research universities, and commercial organizations. Our vision is to transform medical research and clinical care in New York and beyond through the creation of one of the largest genomics facilities in North America, integrating sequencing, bioinformatics, and data management, as well as performing cutting-edge genomics research. 

The New York Genome Center is a VEVRAA Federal Contractor. All qualified applicants will receive consideration for employment and will not be discriminated against on the basis of race, creed, color, gender, religion, national origin, sexual orientation, age, disability, genetic predisposition or carrier status, protected veteran or military status, domestic violence victim status, partnership status, caregiver status, alienage or citizenship status, marital status, or any other characteristic protected by applicable law. The New York Genome Center takes affirmative action in support of its policy to hire and advance in employment individuals who are minorities, women, protected veterans, and individuals with disabilities.

About the Center for Genomics of Neurodegenerative Disease

The Center for Genomics of Neurodegenerative Disease (CGND) is dedicated to the study of neurodegenerative diseases such as ALS and Alzheimer’s disease. CGND’s vision is to establish a center for applying state of the art genetics, genomics, and bioinformatics to the study of neurodegenerative disease mechanisms.  

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