Cold Spring Harbor Laboratory is seeking an experienced research associate for an immediate opening in the Mass Spectrometry Laboratory. This scientist will carry out routine sample preparation and proteomics analysis as well as work with customers to customize protocols and analytical methods for their projects.
The scientist will also be responsible for operation, maintenance and trouble- shooting of the mass spectrometry and HPLC instruments in the core. He or she will broadly apply mass spectrometry approaches in basic research, including cancer, neuroscience, and plant biology fields. The Mass Spectrometry core is equipped with three state-of-the-art mass spectrometers, including an Orbitrap Lumos, a Q Exactive HF and a Vantage Triple Quadrupole.
This individual will join a vibrant group of innovative scientists in a world-renowned research community. This group has broad expertise in various mass spectrometry applications, including protein identification, quantitative proteomics, metabolomics, phospholipid analysis, and PTM identification. The group is led by Dr. Darryl Pappin, a recognized leader in protein chemistry and proteomics, with a strong track record for technology and software development. Pappin was instrumental in the development of the MASCOT software and invention of the isobaric iTRAQ chemistry. In the last few years the Mass Spectrometry group has contributed to a wide variety of discoveries in cancer biology, including the identification of a potential cancer therapeutic from wheat germ extract, identification of a novel persulfide post-translational modification of protein tyrosine phosphatases and elucidation of a mechanism for the role of the CA19-9 carbohydrate in pancreatic cancer.