If you're inspired by the possibilities of science to change lives and you thrive when making brave decisions - join us.
MedImmune is the worldwide biologics research and development arm of AstraZeneca. Here, you'll have the opportunity to make a difference in people's lives every day. As one of the world's premier biotechnology companies, our mission is centered on delivering life-changing products that advance world health, and help fight and cure disease. As a R&D Associate I/II in Gaithersburg, MD you'll play a pivotal role in channeling our scientific capabilities to make a positive impact on changing patients' lives.
We're constantly pushing the boundaries of science to deliver life-changing medicines to patients, with a passion for discovery and a pipeline to show for it. We're pioneering innovative research and exploring novel pathways across key therapeutic areas including oncology, respiratory, inflammation and autoimmunity, cardiovascular and metabolic disease, and infection and vaccines. And we're industry-leading in immunology, protein engineering and translational science. We offer a unique and strong collaborative network as part of the AstraZeneca family, as together we explore synergies between small and large molecules.
MedImmune has a dynamic environment that fosters collaboration and innovation. We attract top minds, and we nurture and build top talent.
Main Duties and Responsibilities
This position involves developing cell culture processes for monoclonal antibodies, vaccines, fusion proteins, and other recombinant therapeutics. The candidate will be an active member of a team responsible for developing and optimizing scalable mammalian cell culture processes for the production of therapeutic proteins and transferring those processes to clinical and commercial sites. Responsibilities will include, but not limited to, routine sub-culture of cells, development of optimized, characterized, and robust seed train and bioreactor processes, media and feed development, harvest development, cell banking, designing of experiments; statistical analysis of data, assessment of product quality, trouble-shooting and developing new technologies. The candidate will contribute to writing development reports such as process description and process characterization reports, summarizing and interpreting results and writing technology transfer documents. The candidate will also assist with compiling data/information and writing CMC sections for regulatory submissions (IND/IMPD/BLA). The candidate will be expected to maintain current knowledge of scientific literature as well as take initiative to identify and solve scientific and technical challenges of the field. The candidate will be expected to present data at internal meetings and, as appropriate, at external conferences. It is expected that the candidate will maintain lab equipment that is used to support lab operations. The use of a lab notebook and the collection of detailed and accurate records are required. A high degree of proficiency in spread-sheet programs and data analysis is expected. Additional responsibilities include ordering chemicals and miscellaneous lab items and keeping track of the key inventory items for ongoing projects.
This position is primarily laboratory-based. Due to nature of cell culture experiments, occasional weekend and holiday work may be required.
Education: Bachelor's or Master's degrees are required in chemical engineering, bioengineering or a related science discipline.
For the R&D Associate I, we require a Bachelor's degree with 0 - 2 years of experience.
For the R&D Associate II, we require a Bachelor's degree with 2 - 5 years of experience OR a Master's degree with 0 - 2 years of experience.
Additional experience required includes fundamental understanding of cell biology and biochemical pathways, excellent team work and communication skills expected, demonstrated skill in multitasking and innovative work and desire to excel are expected, as well as proficiency with MS Office (or related) software.
Experience with aseptic cell culture techniques is strongly desired. Hands on experience at small scale to pilot scale bioreactor operations preferred but not required. Prior use of statistical data analysis preferred.
Cell culture process development experience strongly desired for R&D Associate II candidates.
Next Steps - Apply today!
To be considered for this exciting opportunity, please complete the full application on our website at your earliest convenience - it is the only way that our Recruiter and Hiring Manager can know that you feel well qualified for this opportunity. If you know someone who would be a great fit, please share this posting with them.
AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law. AstraZeneca only employs individuals with the right to work in the country/ies where the role is advertised.