What is the “druggable space” in the human proteome? What proteins can actually be bound by small molecules? How can we determine the mechanism of action of hundreds of small-molecules in an unbiased manner to guide the innovation and characterization of next-generation anti-cancer therapeutics? We hypothesize that a much larger fraction of the proteome is amenable to novel paradigms in drug discovery. The successful applicant will work on these questions as part of and supported by a multi-disciplinary research team. This exciting project is at the vibrant interface between academia and industry, allowing the candidate to achieve a palpable translational impact.