Production Line Specialist

Twist Bioscience
Job Location
San Francisco, CA
Job Description

We are looking for intelligent, motivated, enthusiastic individuals to join our Twist Bioscience Operations Team in San Francisco. The Production Line Specialist will be responsible for the manufacture and analysis of a variety of gene products across Twist Bioscience’s proprietary process workflow to meet the Twist production forecast and timelines. 

The ideal candidate will be driven and will do what it takes to keep manufacturing on track in a fasted paced start-up environment. Appropriate qualified candidate will be considered at a supervisor level with a greater responsibility and as a main point of contact for operators and will provide guidance on priorities and troubleshooting. The Production Line Specialist will produce genes and various intermediates according to established SOPs and complete manufacturing batch records to contribute to the daily production schedule. The production Line Specialist will generate and/or update SOP and batch records to enhance process consistency. The ideal candidate will work independently, be very neat and organized, have excellent molecular biology skills, contribute to process improvement and documentation, and communicate effectively with peers / management.  Knowledge of good laboratory practices (GLPs) is important. The Candidate must be comfortable working in a LEAN manufacturing/ controlled laboratory environment.

Responsibilities include but are not limited to the:

  • Manufacturing of high quality custom gene products in a high throughput MFG lab according to established SOPs.
  • Generate SOPs and batch records to improve process consistency.
  • Check WIP, consult stakeholders to set priorities and prioritize workflow for production personnel.
  • Maintain thorough, accurate and detailed documentation/ databases of all work produced in batch records, databases or other acceptable formats including problems and deviations
  • Operation of basic semi-automated / automated lab equipment for molecular biology workflow
  • Tracking of metrics to track quality of product produced by both physical and functional test methods
  • Understanding of scientific principles in order to problem solve, troubleshoot test results.
  • Keen observation and attitude to proactively identify production problems/ solutions, provide solutions on lab techniques, protocols, processes, handling of product and equipment
  • Upholding standards as defined by the manufacturing process
  • Continuous improvement and good time management resulting in efficiency
  • Support cost improvement initiatives by reducing failures, improving capacity and using supplies wisely. Reduce work in process, queues and cycle times
  • Work in a safe manner
  • Maintenance and calibration of select lab equipment
  • Support production personnel who may have questions and need guidance.
  • Train production personnel on new processes and/or changes to existing processes
  • Work with the materials group to maintain proper levels of production material.

Key Skills required include:

  • Demonstrated knowledge and/or hands on experience with basic lab techniques and equipment/ automation such as: 
    • Sample amplification (PCR, molecular cloning, growing/maintaining cell cultures)
    • Analytical techniques (spectrophotometry/spectrofluorimetry, microscopy, HPLC)
    • Liquid handling (single, multi channel pipetting to robotics, Hamilton)
    • Sequence Analysis: (CE, Gel based methods, arrays, NGS, Sanger sequencing)
    • Oligonucleotide synthesis
  • Sealing and packaging techniques
  • Basic computer skills, especially with excel and MS Office products, statistics, JIRA, Confluence, SAP and MFG databases

Minimum Qualifications

  • Bachelors of Science in Biology, Chemistry or Biochemistry
  • 5+ years lab experience preferably in MFG environment
  • Must be experienced using automation
  • Ability to work in an ISO, GMP, LEAN mfg environment and follow the lean manufacturing concepts
  • Experience in Synthetic Biology workflows is a bonus

Typical Working Conditions are:

  • Team based laboratory environment.
  • Working in controlled laboratory environment.
  • Must be able to stand for long periods of time while performing duties.
  • Must be able to work safely with chemicals and hazardous materials.
  • Must be able to lift up to 30 lbs.
  • Must be able to work outside of regular work hours/ work a flexible shift as needed.
How to Apply

To apply, please visit and apply to be part of Twist !

About Our Organization


At Twist Bioscience, our expertise is accelerating science and innovation by leveraging the power of scale. We have developed a proprietary semiconductor-based synthetic DNA manufacturing process featuring a 10,000-well high throughput silicon platform capable of producing synthetic biology tools, including genes, oligonucleotide pools and variant libraries. By synthesizing DNA on silicon instead of on traditional 96-well plastic plates, our platform overcomes the current inefficiencies of synthetic DNA production, and enables cost-effective, rapid, high-quality and high throughput synthetic gene production, which in turn, expedites the design, build, test cycle to enable personalized medicines, pharmaceuticals, sustainable chemical production, improved agriculture production, diagnostics, biodetection and data storage. For more information, please visit Twist Bioscience is on Twitter. Sign up to follow our Twitter feed @TwistBioscience at

Twist Bioscience is an equal opportunity and an e-verify employer.

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