Process Engineer

Twist BioScience
Job Location
San Francisco, CA
Job Description

Programmable DNA, the software of Life, is finally here! Twist Bioscience is developing a disruptive Synthetic DNA technology that will change the world, enabling widespread health and sustainability. Synthetic biologists will use our products to engineer how organisms produce cures to diseases, everyday chemicals are made using the atmosphere as the carbon source, plants make their own fertilizers, in-vivo diagnostics will alert us when we are sick, and many more applications. Twist is located in Mission Bay, San Francisco’s biotech epicenter. 

We are looking for an outstanding candidate to fill our Member of Technical Staff- Process Engineering position. As a member of the DNA process engineering team, your primary responsibility will be to support the backend hardware necessary for the production of synthetic DNA. You will be responsible for inventing, developing and managing processes involved with nanoliter liquid handling, thermocycling, and purification of synthetic DNA.   Specific responsibilities include: (1) Developing liquid handling systems for nanoliter amounts of synthetic DNA,  (2) Developing tooling, hardware, and software for DNA synthesis and processing, (3) Operation of a range of scientific instruments and tools, and (4) Developing documentation and training instrument operators.



Required Skills:

  • PhD/M.S. / B.S. in Chemical Engineering, Bioengineering, Mechanical Engineering or related field and 5+ years relevant experience
  • In-depth understanding of nanofluidics and microfluidics
  • Understanding of Biochemical processes involved with DNA synthesis and amplification
  • Hands-on skill and demonstrated experience in operating and programming automated lab tools
  • 3D CAD based design skills for developing fixtures
  • Scientific computation skills (matlab, python, etc.)
  • Ability to work with biologists to transfer assays from the research to production
  • Excellent communications skills and ability to work in fast paced team environment

Required Experience:

  • Expert in microfabrication and plastic molding techniques
  • Experience with common biology instrumentation such as PCR, qPCR, capillary electrophoresis,
  • Managing and developing automated liquid handling hardware
  • Data analysis and data visualization capabilities (tableau)

Preferred Experience:

  • Experience with optics and lasers
  • Cell culture hardware support
  • Labview and C++ programming skills
  • Electronic design and debugging skills
  • Solidworks 3D CAD or similar parametric design software
  • Fabrication and machining skills
How to Apply
About Our Organization

At Twist Bioscience, our expertise is accelerating science and innovation by leveraging the power of scale. We have developed a proprietary semiconductor-based synthetic DNA manufacturing process featuring a 10,000-well high throughput silicon platform capable of producing synthetic biology tools, including genes, oligonucleotide pools and variant libraries. By synthesizing DNA on silicon instead of on traditional 96-well plastic plates, our platform overcomes the current inefficiencies of synthetic DNA production, and enables cost-effective, rapid, high-quality and high throughput synthetic gene production, which in turn, expedites the design, build, test cycle to enable personalized medicines, pharmaceuticals, sustainable chemical production, improved agriculture production, diagnostics, biodetection and data storage. For more information, please visit Twist Bioscience is on Twitter. Sign up to follow our Twitter feed @TwistBioscience at

Twist Bioscience is an equal opportunity employer.

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