Process Development Associate II-III

Fred Hutchinson Cancer Research Center & Seattle Cancer Care Alliance
Job Location
Seattle, WA
Job Description

Cures Start Here.
At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch's pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation's first and largest cancer prevention research program, as well as the clinical coordinating center of the Women's Health Initiative and the international headquarters of the HIV Vaccine Trials Network.

Careers Start Here.
An temporary, full-time, Associate position is immediately available in the Process Development group. This role will last for a minimum of 6 months. The position involves the development and optimization of cell processing unit operations including cell selections from starting tissues, genetic modifications (viral transduction, electroporation, etc.), expansion conditions, media/cytokine optimization, cell harvests, cryopreservation, and freeze-thaw recovery. In addition, this position assists in the development of robust and repeatable analytical methods to characterize starting, in-process and final, formulated cellular products. Overall, development activities generate robust, scalable processes to support toxicology studies, transfer and product introduction into a GMP Cell Processing manufacturing facility, and IND generation to enable clinical trial initiation.

As a Process Development Associate, the position acts as a key individual and team contributor within the lab with respect to coordinating activities, ensuring standardized procedures/data analysis, generating technical reports, and defining overall operational efficiency. This position interacts heavily with internal and external research scientists, GMP manufacturing staff, Quality Control/Analytical Development, Quality Assurance, and other scientific staff, as needed.

- BS/MS in an engineering or biological sciences discipline, or equivalent combination of education and experience.
- BS with 5+ years' experience or MS with 3+ years' experience in bioprocess development supporting cell culture based manufacturing operations.
- 3+ years representing the Process Development function on CMC project teams, preferred, not required.

Experience in one or more of the following technical areas:
- Static and/or suspension cell cultures in flasks and bioreactors (fed-batch; fixed and/or disposable bioreactor systems).
- Cell culture media development and optimization studies.
- Associated downstream unit operations such as tangential flow filtration, continuous centrifugation, etc.
- Cryopreservation and recovery of frozen cells.

familiarity with trouble-shooting issues associated with process scale-up and transfer into a GMP manufacturing setting; experience generating process transfer documentation. 

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