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Principal Software Engineer

New York Genome Center
Job Location
101 Avenue of the Americas
New York, NY 10013
United States
Job Description

Position Description

The New York Genome Center is looking for a detail-oriented software engineer to lead our next generation of data processing and pipelining tools.  As an engineer at NYGC, you will be responsible for writing software that follows industry best practices.  You will write extensible, unit-tested software that adheres to the DRY (don’t repeat yourself) principles in a teamwork environment. Principle Software Engineers are project leads, expected to operate under minimal supervision, working under the direction of the technical lead and collaborating with other NYGC software project leads. This includes requirements gathering, planning, setting milestones, and driving the project through to completion. It also entails directing the progress and work patterns of junior engineers and making individual code progress.

The requirements listed below are representative of the knowledge, skill, and/or ability required. 


Including but not limited to, the following:

  • Design and implement software solutions from scratch in object-oriented Python 3 for complicated problems and workflows;
  • Create and analyze existing requirements documents and communicate proposed solutions with team members;
  • Add functionality to existing Python REST APIs in Flask and create new APIs that fulfill business goals; and,
  • Engage in unit testing, integration testing, and validation testing for your software solutions.

Required skills

  • BS in Computer Science, Computer Engineering, or related field;
  • 12+ years related experience; master’s degree plus 10+ years related experience, or equivalent combination of education and experience;
  • Excellent skills in programming extensible object-oriented software solutions using Python 3;
  • Functional familiarity with common open source database systems such as PostgreSQL;
  • Professional work experience with more than one programming language;
  • Experience implementing a software solution from scratch;
  • Experience working with legacy code;
  • Experience writing effective tests for your software;
  • Successful both as an independent contributor and in small teams;
  • Experience directing up to two junior engineers in implementation and maintenance;
  • Experience with common source control systems such as Git;
  • Experience in estimating components and features;
  • Excellent written and verbal communication skills;
  • Comfortable learning a new domain in a short amount of time; and,
  • Comfortable working in an issue-tracking system (e.g. JIRA).


Preferred skills

  • Experience with designing and administering role and permission management systems;
  • Experience with design and implementation of REST APIs, knowledge regarding the different REST-ish approaches;
  • Experience working successfully with contractors;
  • Experience with containers work patterns and administration;
  • Experience with applications involving Clinical data;
  • Experience with HIPAA regulations;
  • Familiarity with application security best practices; and,
  • Familiarity with encryption best cost-effective practices.



  • Job Mastery- Knowledgeable of current role and technical skills, and the impact it has on the Center.
  • Continuous Learning– Strives to expand the depth and breadth of technical and professional skills.
  • Collaborative– Encourages participation from team members and works effectively with all levels.
  • Credible– Works with a high level of integrity.
  • Communicative– Actively listens to others and uses good judgement as to what to communicate to whom; provides feedback.
  • Focused – Utilizes efficient and effective processes.
  • Adaptable– Demonstrate flexibility with changing priorities.
  • Innovative– Develops new insights and pursues improvements.
  • Takes Ownership– Prioritizes tasks, manages time and delivers on commitments.
  • Visionary – Aligns and inspires efforts toward our mission driven organization.
  • Talent Builder – Attracts, develops, empowers and retains talent, and communicates expectations and feedback in real time.  
  • Stewardship – Uses NYGC’s resources responsibly. 


FLSA Status – Exempt

This position is eligible for visa sponsorship and relocation assistance. 


How to Apply

Apply here

About Our Organization

About the New York Genome Center

The New York Genome Center (NYGC) is an independent, nonprofit, academic research organization dedicated to advancing genomic research. NYGC scientists and staff are furthering new approaches to diagnosing and treating neurological diseases and cancer through their unique capabilities in whole genome sequencing, RNA sequencing, state-of-the art analytics, and the development of genomic tools. NYGC concentrates specifically on disease-based research in the following areas: neuropsychiatric disease (autism, schizophrenia, bipolar); neurodegenerative disease (ALS, Alzheimer’s, Parkinson’s, Huntington’s), and cancer.


Located in Lower Manhattan, the New York Genome Center was founded by and remains closely affiliated with twelve leading academic medical centers and research universities in the New York region and beyond, engaging in research projects with and for these institutions. Essential to our collaborative work is an outstanding faculty, whose members typically hold a joint appointment at NYGC and a partner university. They support our scientific mission by conducting independent research in areas of mutual interest to us and the wider scientific community. 


The New York Genome Center is a VEVRAA Federal Contractor. All qualified applicants will receive consideration for employment and will not be discriminated against on the basis of race, creed, color, gender, religion, national origin, sexual orientation, age, disability, genetic predisposition or carrier status, protected veteran or military status, domestic violence victim status, partnership status, caregiver status, alienage or citizenship status, marital status, or any other characteristic protected by applicable law. The New York Genome Center takes affirmative action in support of its policy to hire and advance in employment individuals who are minorities, women, protected veterans, and individuals with disabilities.

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