Pacific Biosciences is seeking a Principal Scientist / Sr. Staff Scientist to join a dynamic team developing next generation DNA sequencing technology. This position is in a fast-paced environment, interacting with R&D and Process Development scientists from a variety of backgrounds. The selected individual will be working toward the development of new products for the Pacific Biosciences SMRT™ sequencing system. This will include working cross functionally to design, plan and execute experiments to evaluate, optimize and integrate sequencing reagents, instrumentation and hardware with the goal of delivering system level improvements to Pacific Biosciences sequencing systems. The position primarily involves hands-on laboratory work and data analysis. Presentation of results at both weekly group and weekly department meetings will be required. The individual will share some responsibilities for laboratory and reagent management.