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Principal Scientist - Medicinal Chemistry

UCB Bioscience
Job Location
795 Massachusetts Ave, Cambridge, MA 02139
Cambridge, MA, MA 02139
United States
competitive compensation package

competitive benefits package

Job Description

We are seeking a talented Principal Scientist – Medicinal Chemistry to join the small molecule medicinal chemistry group located in Cambridge, MA and participate with our multi-disciplinary teams to integrate biological, DMPK and formulation data to accelerate multi-parameter optimization to deliver clinical candidates.


Major Accountabilities/Responsibilities:


  • Conceiving and executing medicinal chemistry initiatives across multiple project phases including hit generation, lead identification and optimization, and ADMET property optimization, all within the context of a target pharmaceutical product profile
  • Analysis of complex data sets and creation of design hypotheses
  • Outstanding leadership, interpersonal, communication, and time-management skills are essential
  • Work with multidisciplinary preclinical development teams to enable the transition from hit to lead candidate as well as final nomination of a clinical candidate

Education and Qualification:


  • MS or PhD in synthetic organic or medicinal chemistry
  • Minimum 7 years of industrial experience in drug discovery and development




  • Previous experience of medicinal chemistry or project leadership preferred
  • Strong written and interpersonal communication skills
  • Ability to communicate effectively and work in a team-based environment
  • Ability to co-ordinate efforts with CROs as well as internal multi-disciplinary teams
  • Demonstrated creativity, inventiveness and innovation in solving problems related to potency, safety and druggability of candidate molecules.
  • Ability to define practical solutions to make go/no-go decisions and effectively communicate program progress within chemistry as well as at larger project team meetings.
  • Experience with structure-based drug design


About Our Organization

About us.


UCB- Inspired by Patients. Driven by Science. Everything we do starts with a simple question: “How will this create value for people living with severe diseases?” By putting patients at the heart of what we do, our approach – from discovery to development to delivery – is continuously transformed and designed around patient needs and their journey.

With a team of approximately 7,500 employees and operations in more than 40 countries, we are a global biopharmaceutical company investing more than a quarter of our revenue in cutting-edge scientific research. We are focused on addressing chronic, neurological, immunological, and bone diseases.


Curious to know more? Please visit our website

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