We are seeking a talented Principal Scientist – Medicinal Chemistry to join the small molecule medicinal chemistry group located in Cambridge, MA and participate with our multi-disciplinary teams to integrate biological, DMPK and formulation data to accelerate multi-parameter optimization to deliver clinical candidates.
- Conceiving and executing medicinal chemistry initiatives across multiple project phases including hit generation, lead identification and optimization, and ADMET property optimization, all within the context of a target pharmaceutical product profile
- Analysis of complex data sets and creation of design hypotheses
- Outstanding leadership, interpersonal, communication, and time-management skills are essential
- Work with multidisciplinary preclinical development teams to enable the transition from hit to lead candidate as well as final nomination of a clinical candidate