Principal Scientist II

Roche Molecular Systems
Job Location
4300 Hacienda Dr
Pleasanton, CA 94588
Job Description

Roche Molecular Systems is seeking an outstanding Principal Scientist in the area of nucleic acid chemistry and biology. The research will involve new molecular diagnostics assay technologies, the development of novel reagents, including automated nucleic acid sample preparation reagents, various chemical analytical processes and methods, PCR-based methods, and cross-functional projects across the entire R&D organization.


The Principal Scientist will work in a team-oriented environment and provide general expertise in nucleic acid chemistry, participate in evaluation of new technologies, and will contribute to improvements of research, assay design, early development strategies, and exploratory technologies. Hands-on experimental skills and demonstrated ability to translate innovation into products or proof of concept are required.



  • Designs and performs experiments to test hypothesis related to project outcomes, and analyzes and interprets data/results.
  • Recommends new or creative approaches, and/or expansion or curtailment of investigations based on experimental data or new scientific information arising from area of responsibility.
  • Participates in project planning, process updates, and experimental design.
  • Assumes responsibility for timely completion of projects, ensuring activities are consistent with project critical path and responding appropriately to changing priorities.
  • Ensures technical activities under delegated supervision are conducted within internal and external guidelines and regulations.
  • Interacts with other departments to further project goals.
  • Accurately and consistently records experimental methods, materials and results in electronic laboratory notebooks.
  • Analyzes data, evaluates results, forms conclusions, and determines future experiments.
  • Presents findings or comprehensive project status reviews at internal seminars/meetings. Applies advanced technical writing skills to produce reports and documents.
  • Prepares summaries, internal reports, presentations, manuscripts, etc.
  • Serves as an expert resource to other departments (e.g., Manufacturing/Operations, Quality, Marketing, Regulatory Affairs, Clinical Studies, and International Technical Services), provides timely response and follow-ups.
  • Participates in the expeditious transfer of products and technologies by providing scientific knowledge and assistance.
  • Provides technical advice/guidance to junior scientific staff, and serves as a role model.

Who you are

You’re someone who wants to influence your own development. You’re looking for a company where you have the opportunity to pursue your interests across functions and geographies. Where a job title is not considered the final definition of who you are, but the starting point.



  • The position requires a minimum of 7 years of research experience with a track record of innovation and peer reviewed publications.
  • A Ph.D. degree in Chemistry, Biochemistry, Chemical Biology, or related field and relevant post-doctoral experience are highly preferred.
  • Experience in POC diagnostics, nucleic acid sample preparation, or stabilization of biochemical reagents is highly desirable.
  • Expertise in molecular evolution techniques, next-generation sequencing, or electrochemistry is a plus.



How to Apply

The next step is yours. To apply online today and to learn about other exciting positions, please go to: and enter Job ID #3092072012 in the “Keyword” box underneath the Global Job Search field or directly at


Roche is an Equal Opportunity Employer

About Our Organization

Who we are

At Roche, 88,500 people across 150 countries are pushing back the frontiers of healthcare. Working together, we’ve become one of the world’s leading research-focused healthcare groups. Our success is built on innovation, curiosity and diversity.

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