Principal Scientist – Clinical Curation / Genomicist

Children's Cancer Institute
Job Location
Job Description

We have an exciting opportunity for a Principal Scientist (Clinical Curation / Genomicist) to join our Zero Childhood Cancer Personalised Medicine Program team on a full-time 24 month fixed term contract with potential to extend.  The Program will generate a large amount of complex genomic, in vitro and in vivo drug response modelling data that requires skilled interpretation, classification, and curation. This position will work closely with the Clinical Fellow and research staff to implement and conduct accurate identification and classification of genomic data in combination with in vitro and in vivo drug response modelling to research and facilitate the determination of actionable treatment recommendations via a multidisciplinary tumour board (MTB).

This role will suit a friendly and outgoing personality who can work with people openly across all components of an organisation. Critical to the role is a clinically orientated and organised approach with an eye for detail, extensive experience in analysis, research, and interpretation of genomic and other complex laboratory data outputs to facilitate the delivery of a comprehensive and meaningful clinical research report to the tumour board and treating clinicians.


Responsibilities will include, but are not limited to:

  • Provide support, training, and knowledge transfer to research staff involved in the annotation and curation process

  • Assessment of pathogenicity and match targets to potential drugs

  • Further develop and streamline the maintenance of variant annotation and curation with the integration of both in vitro and in vivo results

  • Provide support to the Program Leader and Clinical Fellow and work with partner organisations for the development of a comprehensive knowledgebase to house the data generated by the Program

  • Contribute to the development and implementation of policies and procedures related to the interpretation and reporting of multidisciplinary data.

  • Participation in multidisciplinary internal team meetings, and MTB meetings.


We are strongly committed to the growth of our employees so all staff can fulfil their aspirations. You’ll be rewarded with a friendly and professional work environment, comprehensive on-campus facilities, competitive salary, salary packaging options and regular social activities.


Join a group of dedicated people in a performance-driven environment to achieve success and discover what it’s like to look forward to coming to work every day and making a real difference in our mission to save the lives of all children with cancer! It’s not if. It’s when.


A detailed job description and additional information on Children’s cancer Institute can be found on our website at:


Qualifications, experience and skills required:

  • The equivalent of a master’s degree in molecular genetics, human medical genetics, or molecular / genetic pathology with a minimum of 5 years variant classification experience

  • Demonstrated thorough and ongoing knowledge of current theories and principals of human medical genetics, cancer genetics, genetic cancer predisposition, and targeted therapies.

  • Scientific background in biology, molecular mechanisms, and functional studies highly desirable.

  • Demonstrate thoroughness, strong analytical skills, and an ability to understand and interpret data from literature in a critical manner on a daily basis is required.

  • Experience working in a clinical environment and frequent interaction with clinicians and health professionals.

How to Apply

To apply, please go to: and forward both your resume AND cover letter clearly addressing the qualifications, experience and skills required.


About Our Organization

 Children's Cancer Institute is wholly dedicated to putting an end to childhood cancer and is the only medical research institute in Australia solely dedicated to this cause. We don’t just hope to do it – we will do it; and we’re looking for the brightest brains to help us get the job done. Children’s Cancer Institute provides the best possible environment for our staff to develop and thrive with state-of-the-art facilities at the Lowy Cancer Research Centre, UNSW Australia – one of the leading cancer research centres in the world.


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