Principal Engineer 1 – Plastic Consumables Product Development - 7434BR

Illumina, Inc.
Job Location
San Diego, CA 92121
Job Description

Do you want to make a difference? Illumina’s mission is to improve human health by unlocking the power of the genome. If that inspires you, let’s talk. We’ve built a culture fueled by innovation, collaboration and openness, and established ourselves as the global leader in DNA sequencing and array-based technologies. Our people and our technology change lives by driving advancements in life sciences, oncology, reproductive health, agriculture and other emerging markets. Life at Illumina is about working with teammates who are deeply passionate about what we do, because we know that our work has the power to improve lives. We’re an established company with a track record of phenomenal growth. Just check out our investor events and presentations to learn about our financial accomplishments. Our growth isn’t just in financials, we’ve been busy hiring the best and the brightest. Perhaps that’s why MIT has ranked Illumina near the top of its World’s Smartest Companies each of the last three years. If you thrive in a brilliant, fast-paced, and mission-driven environment, Illumina is the place for you. Join the journey of a lifetime. Join Illumina.

This Sr. Staff Engineer will lead mechanical system design as part of a multi-disciplinary team responsible for the development of integrated systems for genetic analysis, with a focus on complex high-volume consumable/disposable devices. Has a strong interest in the full product development cycle, from early innovation and architecture stages through manufacturing transfer and commercialization.


  • Drive requirements definition and architecture development for complex high-volume consumable/disposable devices integrating microfluidics, chemistry and sensing
  • Design, analyze, assemble and qualify consumable/disposable devices, both in prototype quantities and in support of pilot and full-scale manufacturing 
  • Provide technical leadership to project teams
  • Drive selection and qualification of critical partners for product development and manufacturing
  • Perform feasibility studies for throughput, reliability, cost, ergonomics, and product quality
  • Define specifications, critical parameters, test plans, SPC metrics and QC approaches
  • Perform analysis in support of key manufacturing decisions, including make/buy and tooling strategies

 Required Skills & Experience

  • Bachelor’s degree in Mechanical Engineering, Bioengineering, Systems Engineering or related field (advanced degree advantageous)
  • 15+ years of product development experience within an R&D or new product development group, the majority of which involved development of complex high-volume products
  • Experience developing products integrating microfluidics, chemistry/assay and sensing components
  • Experience designing plastic parts and assemblies, and managing development of related manufacturing processes, including injection molding and bonding/joining methods
  • Experience in medical diagnostics product development is a plus
  • Experience designing low-cost assemblies involving machines/mechanisms is a plus
  • Experience developing products with significant human factors considerations
  • Strong skills in Design for Manufacturing; hands-on experience with high-volume manufacturing processes is highly desired
  • Experienced in leading or contributing to a structured development process in a highly collaborative cross-disciplinary team environment
  • Experienced in managing outsourced development and manufacturing relationships




Illumina believes that everyone has the ability to make an impact, and we are proud to be an equal opportunity employer committed to providing employment opportunity regardless of sex, race, creed, color, gender, religion, marital status, domestic partner status, age, national origin or ancestry, physical or mental disability, medical condition, sexual orientation, pregnancy, military or veteran status, citizenship status, and genetic information. If you have a disability or special need that requires accommodation, please contact us at 858-246-8959. To learn more, visit:

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