Multiple positions are available for creative and motivated postdoctoral scholars in the group of Barbara Stranger at The University of Chicago, in the Institute of Genomics and Systems Biology and the Section of Genetic Medicine. The researcher(s) will be involved in integrative analysis of a variety of types of human genomics data, including protein expression, RNA-Seq, DNA-Seq, SNPs, DNA methylation, etc.
Current research in the lab includes (1) genetic basis of gene regulation, (2) transcriptional network and pathway analysis; (3) comparative and population genomics; (4) functional genomic data integration and data mining; and (5) detection of disease susceptibility genes/networks. Project topics include understanding the role of genetic and epigenetic variation on transcriptional regulation in healthy human cohorts and across a variety of cell-types and tissues, the contribution of that variation to higher order phenotypes including cancer and immune and neuropsychiatric diseases, and the role of sex in shaping disease risk, and elucidation of the evolutionary forces shaping functional variation in humans.
We are funded members of the Analysis working group of the NIH Genome Tissue Expression (GTEx) Consortium, and the lab was recently awarded an ‘extended GTEx’ grant to investigate the genetic basis of protein expression in GTEx tissues. We work closely with the Center for Data Intensive Science at the University of Chicago and are members of the Conte Center for Computational Neuropsychiatric Genomics.