The Earlham Institute (EI) has an exciting new role for a Postdoctoral Researcher to join Professor Anthony Hall’s group to work on the following project: Developing a community accessible, powerful computational toolkit for analysis of NGS datasets to study gene families.
The project is a collaboration between Prof. Anthony Hall (Earlham Institute), Dr. Ritesh Krishna (IBM Research UK) and Dr. Alistair Darby (University of Liverpool) and will be based at the Earlham Institute. The Hall lab has recently moved to the Earlham institute, the current focus of the lab is investigating the genetic and epigenetic diversity in bread wheat. The lab also works on the function and underlying mechanism of the circadian clock in model and crop species. The Earlham Institute provides a young and exciting cutting-edge research environment. It applying state of the art technologies to understand biological systems through the application multi-disciplinary approaches including genomics and biological computing.
Use existing bioinformatics tools either developed at the Earlham institute or open source to analyse gene families
• Build and test pipeline components in a cloud environment (Cyverse)
• Use benchmarking datasets from wheat and Tsetse fly to investigate specific gene families, build this analysis into a publication
• Provide documentation and workshop material to allow non-specialist access to the workflows
The project will develop a community accessible, powerful computational toolkit for analysis of NGS datasets to study gene families. The toolkit will leverage information from data to identify novel genic sequences missed by gene prediction software, identify gene annotation errors, and provide an interface for phylogenetic comparison of gene families from related species. Critically it will allow the user to identify members of gene families which are under selection, rapidly expanding or changing in function.