Postdoc position at the Institute of Molecular Medicine: Functional Genomics
Functional genomics laboratory seeking talented postdoctoral researchers to work on exciting projects in regulation of protein translation and small ORF encoded peptides (SEP). The Wang laboratory works on applying and developing genomics methods to study gene regulation (https://www.uth.edu/imm/profile.htm?id=bc360c8f-2189-4ee9-8c96-55602629f14b). The advertised position is for studying potential functions of novel coding regions in the human genome. We have previously identified 7,273 novel coding regions translated in human lymphoblastoid cell lines (https://elifesciences.org/articles/13328). These novel coding regions include SEPs on lncRNA and uORFs that potentially regulate translation of the cognate coding genes. The immediate objective of the project includes a knockout screen for essential function, further proteomics study to validate peptide production, and investigating recent purifying selection at these regions by comparing to data generated from closely related primate species. The long-term goal of the project is to expand our discovery to more tissue types and more species in order to gain a full functional picture of the coding genome.
Other ongoing projects in the lab include cis-QTL mapping to identify genetic variants associated with changes in translation efficiency in response to stress; developing novel methods for inferring RNA binding protein occupancy; developing novel approaches for mutation/ variant detection; developing novel methods for identifying uORF translation. Depending on the interest level and capacity of the recruit, participation in these projects is encouraged.