Postdoctoral Research Associate in Bioinformatics & Immuno-oncology

Case Comprehensive Cancer Center, Case Western Reserve University
Job Location
2103 Cornell Road
Cleveland, OH 44106
Salary is highly competitive and will be accompanied by a comprehensive healthcare and benefits package.
Job Description

A postdoctoral training opportunity is immediately available in the Varadan Laboratory for Cancer Systems Biology at the Case Comprehensive Cancer Center ( If you are captivated by algorithmic approaches to convert terabytes of molecular data into critical biological insights, or are intrigued by integrative models of cancer biology, we are interested in you! Join our team to build upon our recent work including immune signatures predictive of therapy response (Clinical Cancer Research, 2016), large-scale integrative analysis of multi-omics tumor profiles (NPG Oncogene, in press) and multiple translational studies (PNAS, 2015; Cancer Research, 2016).

This postdoctoral opportunity is specifically focused on the integrative analysis of large-scale tumor RNA/DNA sequencing datasets spanning thousands of cancer samples with the goal to identify signatures and mechanisms underlying response targeted and immune checkpoint therapies. You will also be responsible for statistical analysis of molecular profiling data derived from innovative clinical trial datasets and will be involved in writing manuscripts for peer-reviewed journals, preparing for oral presentations at various meetings, and providing assistance with writing grant proposals.

You will be an integral member of a unique collaborative effort involving translational groups in academia and industry, and will interact closely with a multi-investigator team involving clinicians and basic scientists in oncology and immunology. In addition, you will be able to work closely with a highly collaborative team of translational scientists within Case Western Reserve University’s Gastrointestinal Specialized Program of Research Excellence (SPORE) and Barrett’s esophagus Translational Research Network (BETRNet) programs, and will be an integral member of the Cancer Genetics program at the Case Comprehensive Cancer Center.


We are looking for candidates with one or more of the underlying qualifications:

  • PhD in Engineering, Computer Science, Biostatistics, Molecular Biology, or any other relevant biomedical fields with a strong fundamental knowledge of bioinformatics or computational biology
  • Qualified applicants must be fluent in statistical analysis and associated environments such as R or MATLAB
  • Significant exposure to one or more areas of high-throughput molecular profiling data analysis, cancer biology, immunology or DNA/RNA sequencing data analysis will be highly preferred
  • Candidates who are about to graduate, or recent graduates with less than 1-year prior postdoctoral experience are particularly encouraged to apply
How to Apply

Highly motivated individuals should submit via email:

1) A cover letter briefly describing their career goals and research background (maximum 1 page)

2) Curriculum Vitae

3) Contact information for 3 references 



Vinay Varadan, PhD

Assistant Professor, Case Comprehensive Cancer Center Case Western Reserve University 2103 Cornell Rd, Cleveland, OH 44106


About Our Organization

The Varadan Lab for Cancer Systems Biology ( is a growing collaborative team of engineers, biologists, programmers and scientists dedicated to solving some of the most complex problems in translational cancer research through the integration of innovative data science with deep biological knowledge.  Our ongoing collaborations within the Case Comprehensive Cancer Center, one of only 46 NCI-designated Comprehensive Cancer Centers in the United States, spans the translational spectrum, from clinicians to engineers and molecular biologists, thus allowing us to traverse the journey from bedside-to-computer-to-bench and then back-to-bedside.

In employment, as in education, Case Western Reserve University is committed to Equal Opportunity and Diversity.  Women, veterans, members of underrepresented minority groups, and individuals with disabilities are encouraged to apply.

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