We seek motivated, creative and bright individuals, to work at the Framingham Heart Study. The FHS, has a wealth of genetic and OMICs data including whole genome sequence data, transcriptomes (microarray and RNA-seq), methylome, lipidome, metabolome, microbiome and proteome. Additionally, the Johnson Lab has led the collection of the largest global samples to date on platelet function and platelet reactivity, both within FHS and other cohort samples. Relevant future research project areas for Fellows include the genetics of platelet function, pharmacogenetics of anti-platelet therapy, integration of platelet transcriptome and other OMICS data with cardiovascular risk and platelet function data, risk prediction of cardiovascular disease based on platelet biomarkers, and the relationship between platelet biomarkers and clinical bleeding history. Additional epidemiological questions relate to how platelets change in aging, ethnic differences in platelet function, the influence of platelet function on cancer risk, and the role of physical activity, dietary intake and other environmental factors on platelet function.
We collaborate widely with several Domestic and International Consortia in the area of Hematology (cell counts), Hemostasis (clotting factors), and cardiovascular risk (MI, stroke, VTE). We are co-leading genetic projects on platelet counts in ~1.2 million individuals in sample size to generate new target genes controlling platelet biogenesis and decay. We partner with stem cell collaborators, zebrafish and mouse geneticists for functional studies to follow up human platelet genetic discoveries.
The successful candidate will be offered a competitive salary commensurate with experience and qualifications. The initial appointment will be for a minimum of 2 years, with appointment renewals in 1-year increments. The post-doc must be a US citizen, resident alien, or nonresident alien who obtains a valid employment visa.