The group of M.Mar Albà (http://evolutionarygenomics.imim.es) is seeking postdoctoral candidates for a project to identify new antimicrobial peptides in the human genome using deep RNA sequencing. Antimicrobial peptides (AMPs) are short proteins produced by a wide range of organisms that have the capacity to kill bacteria (Wiesner and Vilcinskas 2010). They are a promising alternative to classical therapeutic antibiotics, as bacteria have not developed highly effective resistance mechanisms to these natural substances (Peschel and Sahl 2006). Due to their short size (∼12-50 amino acids), AMPs are difficult to detect by genome annotation efforts or high througput proteomics. The aim of this project is to discover and characterize new AMPs in the human genome using deep RNA sequencing (RNA-seq) and computational methods. Putative AMPs will be identifed using measurements based on the codon usage bias (Ruiz-Orera et al., 2014) and sequence-based AMP activity prediction. Using comparative genomics we will search for adaptive substitutions that may have increased AMP activity the over time (Gayà-Vidal and Albà, 2014). Promising candidates will be experimentally validated. Gayà-Vidal M and Albà MM. 2014. Uncovering adaptive evolution in the human lineage. BMC Genomics 15: 599. Ruiz-Orera J, Messeguer X, Subirana JA, Albà MM. 2014. Long non-coding RNAs as a source of new peptides. eLife Sep 16;3.