Postdoctoral opportunity in Epigenetics of Intestinal Stem Cells, Discovery Safety

AstraZeneca Pharmaceuticals
Job Location
Waltham, MA
Job Description

We're currently looking for talented scientists to join our innovative academic-style Postdoc. From our centre in Waltham, MA you'll be in a global pharmaceutical environment, contributing to live projects right from the start. You'll take part in a comprehensive training programme, including a focus on drug discovery and development, given access to our existing Postdoctoral research, and encouraged to pursue your own independent research in cutting edge laboratories. It's a newly expanding programme spanning a range of therapeutic areas across a wide range of disciplines.

What's more, you'll have the support of a leading academic advisor, who'll provide you with the guidance and knowledge you need to develop your career. This is an exciting area that hasn't been explored to its full potential, making this an opportunity to make a real difference to the future of medical science.

About AstraZeneca
AstraZeneca is a global, innovation-driven biopharmaceutical business that focuses on the discovery, development and commercialisation of prescription medicines for some of the world's most serious diseases. But we're more than one of the world's leading pharmaceutical companies. At AstraZeneca, we're proud to have a unique workplace culture that inspires innovation and collaboration. Here, employees are empowered to express diverse perspectives - and are made to feel valued, energised and rewarded for their ideas and creativity.

In this postdoc, you will have the opportunity to identify the transcriptional machinery that enables the pluripotent and self-renewing capabilities of some of the most actively dividing adult stem cells in the human body. Your work will utilize cutting edge molecular and cellular biology techniques to dissect essential elements of stem cell epigenetics in the intestine. In addition to uncovering as of yet undiscovered frontiers in stem cell biology, your postdoc will directly contribute to understanding the dose-limiting toxicities that will make, or break, an entirely new class of oncotherapeutics.

As aPostdoctoral Scientist -- Epigenetics of Intestinal Stem Cells, Discovery Safety, you will be:

Defining essential epigenetic regulators of intestinal stem cells using in vitro, in vivo, and in silico methodologies
Using bioinformatics to identify key transcriptional regulators of intestinal stem cell self-renewal
Testing the essentiality of the identified genes in cutting-edge organoid systems, and identifying their key downstream targets
Verifying findings in vivo using transgenic animal systems
Publishing all findings in high-impact peer-reviewed scientific journals
Working collaboratively with experts internally and externally across various disciplines to aid ongoing project initiatives
Presenting results externally at scientific conferences and meetings


As aPostdoctoral Scientist -- Epigenetics of Intestinal Stem Cells, Discovery Safety, it's essential that you have:
A PhD in a relevant discipline, such as molecular biology, physiology, pharmacology, toxicology, or related discipline
Expertise with standard molecular biology techniques, including mammalian cell culture
A proven scientific track record of publications in reputable scientific journals
Commitment to medical sciences
The following skills and qualifications are desirable:
Experience with epigenetics and transcriptional biology
Bioinformatics expertise
Previous experience with culturing stem cells and/or organoid systems
Knowledge of cell signaling pathways

Equal Opportunity Employer Minorities/Women/Protected Veterans/Disabled/Sexual Orientation/Gender Identity
LocationMA, Waltham
CategoryResearch and Non-Clinical Development
Date Posted2/9/2015
Req Number15-50098665
NoticeAstraZeneca does not accept non-solicited resumes or candidate submittals from search/recruiting agencies not already on AstraZeneca's approved agency list. Unsolicited resumes or candidate information submitted to AstraZeneca by search/recruiting agencies not already on AstraZeneca's approved agency list, and who were not asked to work on a specific vacancy, shall become the property of AstraZeneca and if the candidate is subsequently hired by AstraZeneca, AstraZeneca shall not owe any fee to the submitting agency.

AstraZeneca is a global, innovation-driven biopharmaceutical business that focuses on the discovery, development and commercialisation of prescription medicines, primarily for the treatment of cardiovascular, metabolic, respiratory, inflammation, autoimmune, oncology, infection and neuroscience diseases. AstraZeneca operates in over 100 countries and its innovative medicines are used by millions of patients worldwide. For more information please visit

Making a Difference
AstraZeneca is an equal opportunity employer

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