Come work at the exciting interface of synthetic biology and high throughput immunology!
The Larman laboratory develops and deploys new technologies to study the human immune system. Much of our work utilizes 'next generation' DNA sequencing to enable novel, massively parallel molecular assays. Examples of these technologies include:
- phage display of synthetic peptidome libraries for comprehensive, quantitative profiling of antibodies;
- ribosome display of ORFeome libraries for antigen discovery, protein-protein interaction studies, and drug target identification;
- ultrasensitive, multiplex RNA quantification techniques to monitor gene expression and infectious microbes;
- pooled genetic screening to elucidate immune cell function and identify new therapeutic targets.
The laboratory uses these and other massively parallel approaches to identify new opportunities for monitoring and manipulating immune responses.