Postdoctoral fellowship in the genetics of neurodegenerative disease

Icahn School of Medicine at Mount Sinai
Job Location
New York, NY 10129
Job Description

The Ronald M. Loeb Center for Alzheimer’s Disease, directed by Dr. Alison Goate, at the Icahn School of Medicine at Mount Sinai is seeking a passionate individual to investigate the neuropathology and genetics of neurodegenerative tauopathies. We are using advanced genomic and computational approaches to identify novel drivers of disease pathogenesis. This NIH-funded project focuses on understanding the overlap between Alzheimer's disease, Parkinson’s disease, and other neurodegenerative diseases.  The candidate will join a highly productive research team that includes geneticists, computational biologists, cell biologists and physician-scientists at the Loeb Center. The successful candidate will be play an active role in deploying next-generation sequencing data (DNA and RNA) and correlating with novel endophenotypes to elucidate pathogenic drivers.


Responsibilities: 1. To assist in the design of genomics experiments, 2. To analyze publically available and novel genomic datasets, including quality control and variant identification and annotation, associated with neuropathological outcomes and etiology using existing computational resources in R and other programs, 3. To work towards development of independent scientific ideas and post-doctoral appropriate grants (e.g., K award, R03), with a long term goal of independent investigator status.

  1. Experience with genetics and a recent doctoral degree (e.g,. PhD) in computational biology, computer science, genetics, epidemiology, biostatistics, bioinformatics or related field.  Alternatively an MD with relevant additional relevant experience
  2. Expertise in R and R/Bioconductor and a scripting language (e.g., perl/python) in a Unix environment
  3. An interest in working with a diverse group of scientists to advance our understanding of neurodegenerative diseases through a synergy of wet and dry lab approaches


About Our Organization

The Raj Laboratory is a member of the Ronald M. Loeb Center for Alzheimer's Disease, Departments of Neuroscience, Genetics, and Genomic Sciences, Institute for Genomics and Multiscale Biology, and Friedman Brain Institute at Icahn School of Medicine at Mount Sinai. The research in the Raj lab focuses on mechanisms underlying the regulation of gene expression and how these mechanisms are disrupted in neurodegenerative diseases. More info:

The Institute for Genomics and Multiscale Biology at the Icahn School of Medicine at Mount Sinai seeks to comprehensively integrate the digital universe of information into research, training, and patient care and to develop programs that prepare students for careers in the future of healthcare and data science.

The Mount Sinai Health Systemis committed to the tenets of diversity and workforce that are strengthened by the inclusion of and respect for our differences. We offer our employees a highly competitive compensation and benefits package, a 403(b) retirement plan, and much more.


Formed in September 2013, Mount Sinai Health System combines the excellence of the Icahn School of Medicine at Mount Sinai with 7 premier hospital campuses, including Mount Sinai Beth Israel, Mount Sinai Beth Israel Brooklyn, The Mount Sinai Hospital, Mount Sinai Queens, New York Eye and Ear Infirmary of Mount Sinai, Mount Sinai Roosevelt, and Mount Sinai St. Luke’s.


The Mount Sinai Health System is an equal opportunity employer. We promote recognition and respect for individual and cultural differences, and we work to make our employees feel valued and appreciated, whatever their race, gender, background, or sexual orientation.   EOE Minorities/Women/Disabled/Veterans





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