The Karr lab in the Institute for Genomics & Multiscale Biology at the Mount Sinai School of Medicine is seeking talented, ambitious individuals to develop cutting-edge dynamical models of human and bacterial cells. Despite the explosion of experimental data, we do not comprehensively understand how phenotype arises from genotype. Our approach is to develop computational models which predict how behavior emerges from the molecular level by integrating diverse data into a single model. Our goal is to use models to make medicine more precise and personalized by predicting disease progression and drug responses. We are also using our models to engineer bacteria. Our research is highly interdisciplinary involving computational modeling, software engineering, data visualization and curation. We have close collaborations with several experimental groups to build and test our models.
Two positions are available in human and bacterial whole-cell modeling. The human whole-cell modeling scientist will be responsible for developing whole-cell models of human cancer cells. The bacteria whole-cell modeling scientist will be responsible for developing a whole-cell model of Mycoplasma pneumoniae and using the model to design Mycoplasmas for bacterial-based drug delivery. This will include expanding the scope of our existing whole-cell models, incorporating new sources of high-throughput genomic data, and improving the accuracy of whole-cell models. The scientists will work closely with software developers to design a software platform for whole-cell modeling. The cancer scientist will also collaborate with experimental cancer systems biologists at Mount Sinai. The bacterial scientist will also collaborate with Luis Serrano's laboratory at the Center for Regulatory Genomics in Barcelona, Spain.