Postdoctoral Positions in genomics and molecular biology are available in the Beyster Center for Genomics of Psychiatric Disease and the Institute for Genomic Medicine at UC San Diego (http://igm.ucsd.edu). Our laboratory is developing novel approaches for the identification of risk genes for neuropsychiatric disorders, and we are initiating a genetic study to investigate how variation within the “dark matter” of the genome contributes to risk for human disease. We seek to understand the genetic basis of disease by Whole Genome Sequencing (WGS) in families, and by integrating data on de novo mutation and inherited genetic variation, including copy number variants (CNVs), nucleotide substitutions and indels (http://sebatlab.ucsd.edu/research). We are currently leading multiple large scale genetic studies of autism and schizophrenia.
This Postdoctoral position will lead a Next Generation Sequencing effort investigating the role of non-coding genetic regulatory elements in the etiology of autism. We seek to understand how genetic alterations impact gene regulation at level of transcription, translation and mRNA processing. Central to these studies is the development and implementation of novel high-throughput methods for genomic analysis including, high-throughput sequencing of patient cohorts using padlock-probe probe target capture, identification of disease causing mutations by analysis of large genomic datasets, and the development of novel molecular methods for high-throughput functional analysis of cis regulatory elements.