Postdoctoral Fellows: Genomics – High-Throughput Sequencing

Organization
UCSD
Job Location
La Jolla, CA 92093
Job Description

Postdoctoral Positions in genomics and molecular biology are available in the Beyster Center for Genomics of Psychiatric Disease and the Institute for Genomic Medicine at UC San Diego (http://igm.ucsd.edu). Our laboratory is developing novel approaches for the identification of risk genes for neuropsychiatric disorders, and we are initiating a genetic study to investigate how variation within the “dark matter” of the genome contributes to risk for human disease. We seek to understand the genetic basis of disease by Whole Genome Sequencing (WGS) in families, and by integrating data on de novo mutation and inherited genetic variation, including copy number variants (CNVs), nucleotide substitutions and indels (http://sebatlab.ucsd.edu/research). We are currently leading multiple large scale genetic studies of autism and schizophrenia.

 

This Postdoctoral position will lead a Next Generation Sequencing effort investigating the role of non-coding genetic regulatory elements in the etiology of autism. We seek to understand how genetic alterations impact gene regulation at level of transcription, translation and mRNA processing. Central to these studies is the development and implementation of novel high-throughput methods for genomic analysis including, high-throughput sequencing of patient cohorts using padlock-probe probe target capture, identification of disease causing mutations by analysis of large genomic datasets, and the development of novel molecular methods for high-throughput functional analysis of cis regulatory elements.

How to Apply

We are seeking a talented and highly motivated scientist with an interest in developing and applying new molecular approaches to large-scale genetic studies. Excellent molecular biology laboratory skills, familiarity with genome informatics tools, and a strong publication record are required. A 25% salary increase is given to postdoc appointees that are successful in obtaining a postdoctoral fellowship.

 

Applicants should send a CV and a list of three references by email to [email protected].

Jonathan Sebat, Ph. D.

[email protected]

Chief, Beyster Center for Molecular Genomics of Neuropsychiatric Diseases
 Institute for Genomic Medicine

Associate Professor
Department of Psychiatry
Department of Cellular and Molecular Medicine
University Of California, San Diego
La Jolla, CA 92093-0667



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