A postdoctoral position is available in the laboratory of David N. Levy, PhD at New York University College of Dentistry.
Utilizing a multi-omics approach, we are investigating the contribution of viral and cellular factors to the decision between productive and latent HIV infection. At the epigenetic level, we have identified specific viral factors that regulate the initial installation of chromatin post-translational modifications influencing early viral gene expression. In combination with ChIP-PCR and cellular transcriptomics (single cell and bulk RNA-seq, ATAC-seq, etc.), and proteomics, we are elucidating key pathways governing viral replication and persistence. Understanding the interplay between viral and cellular epigenetic regulators is key to developing novel methods to activate or suppress expression from viral reservoirs.