Postdoctoral Fellow in Stem Cell Biology and Pharmacogenomics
A postdoctoral fellow position is available in the laboratory of Dr. Paul Burridge in the Department of Pharmacology and the Center for Pharmacogenomics at Northwestern University Feinberg School of Medicine, Chicago, IL.
Successful candidates will participate in NIH- and AHA-funded projects to study the application of human induced pluripotent stem cells (hiPSC) in predictive medicine. Our goal is to develop the next generation of tools for predicting drug responses and validating SNPs to allow the use of genomic information in precision medicine and drug discovery. With these data we will probe the mechanisms of action of a range of drugs to provide individualized treatment selections and regimens to improve drug efficacy and eliminate off-target toxicity.
We are looking for highly motivated and creative candidates with an interest in studying SNPs and molecular mechanisms involved in chemotherapy-induced toxicity (primarily cardiovascular) of tyrosine kinase inhibitors and monoclonal antibodies using patient-specific hiPSC-derived cells. Projects will utilize a wide range of state-of-the-art techniques such as genome editing, high-content imaging, high-throughput drug screening, electrophysiology, whole genome sequencing, RNA-seq, and eQTL. The Burridge Laboratory is stably supported by NIH, AHA, and institutional funding. More about the lab can be found here: http://burridgelab.com/