The Karr Lab at the Institute for Genomics & Multiscale Biology at the Icahn School of Medicine at Mount Sinai is seeking talented, ambitious researchers to develop cutting-edge whole-cell computational models of individual cells, as well as new technologies to enable larger and more accurate whole-cell models. Despite the explosion of experimental data, we do not understand the details of how phenotype arises from genotype and the environment. We are developing whole-cell computational models which comprehensively predict how behavior emerges from the molecular level by representing all of the biochemical activity inside cells. Our goal is to use whole-cell models to transform bioengineering and medicine into rigorous, quantitative disciplines. For example, we believe that whole-cell models could enable bioengineers to design microbial genomes for a variety of industrial applications, as well as enable physicians to tailor medical therapy to individual patients. Our research is highly interdisciplinary, involving systems biology, genomics, bioinformatics, data integration, parallel simulation, optimization, software engineering, and data visualization, and highly team-oriented.
To enable larger whole-cell models, including models of human cells, the Postdoctoral Fellow/Engineer will develop new methods for simulating large, multi-algorithmic whole-cell models. This will include developing a new algorithm for concurrently integrating mathematically heterogeneous submodels that share state and implementing this as a high-performance, parallel simulation software system. The Postdoctoral Fellow/Engineer would work closely with our team at Mount Sinai, as well as our parallel simulation collaborators Drs. Peter Barnes and David Jefferson at Lawrence Livermore National Laboratory and our broader international team of collaborators. The Postdoctoral Fellow/Engineer would also have many opportunities to work with our team to build and analyze whole-cell models.