Postdoctoral Fellow on improving the understanding of systemic melanoma-mediated immune suppression by deep serum profiling

Organization
Utrecht University - Altelaar lab
Job Location
Padualaan 8
3584CH Utrecht
Netherlands
Job Description

In this project we aim to identify soluble factors present in melanoma patients’ plasma, that are responsible for systemic immune suppression, which hampers T cell activation upon checkpoint inhibitor treatment. In a collaborative effort with the NKI we will analyze systemic treatment naïve plasma samples by deep proteomic profiling from stage III melanoma patients that have progressed to stage IV. Changes in the profile of the identified proteins will be tested in an independent cohort of 100 melanoma patients treated with ipilimumab+nivolumab from whom we have collected baseline serum samples. 

Requirements

The candidate should hold a PhD in biochemistry, cell biology, systems biology, biotechnology or a related field and have experience in high-end proteomics workflows. Prior expertise with blood, serum and/or plasma sample handling is preferred. Candidate should have a strong publication record, excellent communication skills and the willingness to work in a team.

How to Apply

Submit a CV and motivation letter to [email protected]

About Our Organization

A better future for everyone. This ambition motivates our scientists in executing their leading research and inspiring teaching. At Utrecht University, the various disciplines collaborate intensively towards major societal themes. Our focus is on Dynamics of Youth, Institutions for Open Societies, Life Sciences and Sustainability.

The city of Utrecht is one of the oldest cities in the Netherlands, with a charming old center and an internationally oriented culture that is strongly influenced by its century-old university. Utrecht city has been consistently ranked as one of the most livable cities in the Netherlands.

 

The Faculty of Science consists of six departments: Biology, Pharmaceutical Sciences, Information and Computing Sciences, Physics and Astronomy, Chemistry and Mathematics. The Faculty is home to 5600 students and nearly 1500 staff and is internationally renowned for the quality of its research. The Faculty's academic programmes reflect developments in today's society.

 

The Utrecht Institute for Pharmaceutical Sciences (UIPS) is the research institute of the Department of Pharmaceutical Sciences of Utrecht University. UIPS focuses on processes around discovery, development, and use of drugs and medical nutrition using molecular and technological principles from the Natural and Life Sciences. This research is ideally positioned in the Faculty of Science to work on basic scientific problems and to translate new findings into potential solutions to urgent societal medical needs, which are addressed in the Faculties of Medicine and Veterinary Medicine. Every year around 400 peer-reviewed articles are published and around 30 PhD candidates defend their thesis. UIPS is partner in several open source innovation networks.

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