We are looking for an outstanding cancer genomics/bioinformatics scientist with experience in analysis of next generation sequencing including exome, whole genome and RNASeq data. The selected candidate will take a leading role in a project funded by Cancer Research UK as a component of a “Grand Challenge” to assess the impact of environmental carcinogens on mutation signatures in mouse and human cancers. This is a multidisciplinary project involving specialists in cancer biology, genetics and computational biology with two major goals: 1) to identify mutation signatures of carcinogens in mouse tumors induced by known or suspected human carcinogens and compare these with large databases of human mutation signature data; 2) to explore the mechanisms by which non-mutagenic agents, including chemicals, inflammation, obesity or other co-factors in cancer causation may act to promote tumor development. The successful candidate will take a lead role in key aspects of these projects and will require strong motivation, intellectual independence and a strong work ethic. She/he should have an excellent track record of scientific achievement.