We are looking for an experienced statistical geneticist or genetics aware computational biologist post-doctoral fellow to join the Birney research group at EMBL- EBI to work on a multi-national NIH funded research project to exploring environmental toxicology – MedakaTox.
Over the last seven years dedicated work has led to the establishment of the first near-isogenic panel from a wild fish population in vertebrates, the inbred medaka MIKK panel. This resource provides a unique opportunity for studying the genetic and gene-environment (GxE) effects of environmental contaminant response in a wild-derived vertebrate population.Your roleIn this project we will focus on two specific phenotypes, a heart rate and a skeletal assay, testing a range of dosage exposures for 10 or more environmental compounds known to affect the heart, skeleton, or both. For association testing we will use leading genetic techniques, in particular linear mixed models with multi-trait phenotypes, to maximize discovery. High-throughput phenotyping across the MIKK panel will be followed by specific breeding strategy designs and genome sequencing to maximize power for mapping effects to loci.
The project will influence the design and interpretation of human GxE studies, where it is impossible to control exposure, and will provide a comprehensive view of the genetic architecture of the GxE effects.