A postdoctoral position is available in the group of Dirk Fasshauer at the Department of Fundamental Neurosciences, University of Lausanne. The group is investigating the conserved protein machinery involved in the fusion of transport vesicles in eukaryotic cells, in particular the proteins driving the release of neurotransmitters from synaptic vesicles. To come to a better understanding, we focus on a detailed biochemical characterization of the underlying protein-protein interactions. In the past few years we picked up computational methods to complement our research (e.g. http://bioinformatics.mpibpc.mpg.de/rab/). The key objective of this approach is to establish a detailed evolutionary description of the vesicle fusion machinery. We want to uncover how the interaction network has adapted in different eukaryotic lineages and how it was most probably organized in the proto-eukaryotic cell. For our approach, we have developed a unique system to classify protein families. The basis of the system is a MySQL database and a package of Java classes to store and access the information. Sequences are analyzed through iterative use of hidden Markov models, cluster and phylogenetic analysis.