We are seeking to recruit a Postdoctoral Fellow for a position in computational cancer genomics in the Open Targets team, located on the Wellcome Genome Campus, near Cambridge, UK.
The project is a collaborative effort involving teams in the Wellcome Trust Sanger Institute, the European Bioinformatics Institute, GlaxoSmithKline, and Biogen, through a public-private initiative aiming at generating evidence on the validity of therapeutic targets, and is committed to sharing its data openly with the scientific community.
Large panels of immortalised human cancer cell lines, and more recently, 3D in vitro models (such as cancer organoids) are routinely used in oncology research, including on going and proposed projects at Open Targets. Recent studies have revealed a high degree of variability in the correlation between the molecular features of these models and those characterising the primary tumours they aim to represent. This has implications for the quality of target data emerging from studies using such models.
You will apply existing and develop novel algorithms and computational tools for ranking in vitro model similarities to primary diseases, to make appropriate informed choices about model inclusion/exclusion in retrospective and prospective analyses, and to identify disease subtypes currently lacking appropriate in vitro models.