A Postdoctoral position in computational biology/genomics is available in the Statistical Genomics and Systems Genetics group (http://www.ebi.ac.uk/stegle) at the European Bioinformatics Institute (EMBL-EBI) located on the Wellcome Trust Genome Campus near Cambridge in the UK.
The group is developing statistical approaches to unravel the relationship between genetic variation data, molecular traits and disease phenotypes. The project is funded by the Centre for Therapeutic Target Validation (CTTV), a three-way collaboration between EMBL-EBI, the Wellcome Trust Sanger Institute (WTSI) and GlaxoSmithKline (http://www.targetvalidation.org). This is a public-private initiative to generate evidence on the validity of therapeutic targets, and is committed to sharing its data with the scientific community.
The fellow will work in the Stegle group and collaborate closely with the Ensemble team (www.ensemble.org) at the EBI, developing analytical strategies for tying together genetic associations with molecular traits such as gene expression levels (eQTLs) and epigenetic marks, integrating information on 3d chromatin interactions. The primary goal is to derive new analytical strategies to fully harness the datasets that are being generated and curated within the CTTV, thereby studying tissue-type specific effects of regulatory variants in the human genome.
EMBL-EBI is part of the European Molecular Biology Laboratory (EMBL); we are a world-leading bioinformatics centre providing biological data to the scientific community with expertise in data storage, analysis and representation. We provide a dynamic, international working environment and have close ties with both the University of Cambridge and the Wellcome Trust Sanger Institute. EMBL-EBI staff enjoy many benefits including excellent sports facilities, a free shuttle bus to Cambridge and other nearby centres, an active sports and social club and an attractive working environment set in 55 acres of parkland.