Postdoctoral Fellow

Organization
EMBL-EBI
Job Location
Wellcome Trust Genome Campus
Hinxton
Cambridge
Cambridgeshire
CB10 1SD
United Kingdom
Salary
Competitive
Job Description

A Postdoctoral position in computational biology/genomics is available in the Statistical Genomics and Systems Genetics group (http://www.ebi.ac.uk/stegle) at the European Bioinformatics Institute (EMBL-EBI) located on the Wellcome Trust Genome Campus near Cambridge in the UK.

 

The group is developing statistical approaches to unravel the relationship between genetic variation data, molecular traits and disease phenotypes. The project is funded by the Centre for Therapeutic Target Validation (CTTV), a three-way collaboration between EMBL-EBI, the Wellcome Trust Sanger Institute (WTSI) and GlaxoSmithKline (http://www.targetvalidation.org). This is a public-private initiative to generate evidence on the validity of therapeutic targets, and is committed to sharing its data with the scientific community.

 

The fellow will work in the Stegle group and collaborate closely with the Ensemble team (www.ensemble.org) at the EBI, developing analytical strategies for tying together genetic associations with molecular traits such as gene expression levels (eQTLs) and epigenetic marks, integrating information on 3d chromatin interactions. The primary goal is to derive new analytical strategies to fully harness the datasets that are being generated and curated within the CTTV, thereby studying tissue-type specific effects of regulatory variants in the human genome.

 

EMBL-EBI is part of the European Molecular Biology Laboratory (EMBL); we are a world-leading bioinformatics centre providing biological data to the scientific community with expertise in data storage, analysis and representation. We provide a dynamic, international working environment and have close ties with both the University of Cambridge and the Wellcome Trust Sanger Institute. EMBL-EBI staff enjoy many benefits including excellent sports facilities, a free shuttle bus to Cambridge and other nearby centres, an active sports and social club and an attractive working environment set in 55 acres of parkland.

Requirements

The successful applicant will hold a doctoral degree or equivalent qualification in computer science, statistics, mathematics, physics, and/or engineering, or a degree in biological science with demonstrated experience in computational and statistical work.

 

Previous experience in developing and applying computational methods in the context of genomics analyses is expected. Expertise in analysis and integration of multiomics data, statistical interpretation and analysis of next-generation sequencing datasets is beneficial, as is communicating results in scientific conferences and papers.

 

We especially seek candidates with prior experience in statistical aspects of genomics, including genetics,  gene expression data analysis, GWAS and analysis of NGS data. A good foundation in, and previous usage of methods in any of the following fields is advantageous: statistics, machine learning, genetics, optimization and mathematical modelling A background in molecular biology, or previous experience tackling biological questions is beneficial but not necessary.

 

Proficiency with a high-level programming language (e.g. C++, Java) and/or appropriate scripting languages, and statistical data analysis tools such as R, MATLAB or Python is required.

 

The ideal applicant should have demonstrated the ability to work independently and creatively. (S)he should have excellent communications skills and be able to articulate clearly the scientific and technical needs, set clear goals and work within an interdisciplinary setting, communicating with other partners within the CTTV

How to Apply

Please apply online through www.embl.org/jobs

About Our Organization

EMBL-EBI staff enjoy many benefits including excellent sports facilities, a free shuttle bus to Cambridge and other nearby centres, an active sports and social club and an attractive working environment set in 55 acres of parkland.

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