Postdoctoral Associate

Broad Institute
Job Location
Cambridge, MA
Job Description

Our research teams here are working on redefining the boundaries of science and medicine with an interdisciplinary model designed to meet today’s most critical biomedical challenges. Here you will find a supportive and collaborative intellectual environment and a firm commitment to continuously invest in cutting edge technology. The mission of the Stanley Center for Psychiatric Research at the Broad Institute is to decrease the burden of psychiatric disorders through research. We aim to exploit the significant role of genetics in the pathogenesis of psychiatric diseases as an effective window into their biology and as clues to new therapeutics. The Center has extensive collaborations investigators both within the local Harvard and MIT communities and more broadly across the world

The successful candidate will work within the Stanley Center for Psychiatric Research to develop and apply methods to characterize the function of ion channels that harbor genetic variations associated with psychiatric disorders, in both heterologous expression system as well as primary neurons. Further, the candidate will investigate the biological impact of genetic variations of ion channels in vitro and in vivo in neurons. The researcher will be responsible for communicating results to the scientific community through conference presentations and publications, and within Broad Institute internal communications.

• Develop and implement cellular assays and electrophysiological protocols to analyze genetic variants in ion channels and the role of such variation in the disease pathogenesis of psychiatric disorders
• Publish scholarly reports and present at scientific conferences.
• Participate within a team of scientists to foster a culture of scientific discourse and excellence.
• Interact and coordinate with collaborators as required.

Other related tasks as need.

• Ph.D. (0-1 years post-grad) in Neuroscience, Cell biology or related field. Experienced in ion channel physiology and electrophysiological techniques such as whole cell patch clamp. Quantitative analysis, such as ion channel kinetic modeling and single channel analysis is strongly desired.
• Proficient in primary neuronal cultures. Experience with slice physiology desired.
• Excellent communication skills and the ability to interact professionally with all levels of staff and with external contacts in a fast paced environment required.
• Exceptional organizational and critical thinking skills, lab notebook practices and attention to detail are essential.
• All successful candidates must have a “can do” attitude and good problem solving skills.

EOE/Minorities/Females/Protected Veterans/Disabilities

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