Cold Spring Harbor Lab
Job Location
One Bungtown Road
Cold Spring Harbor, NY 11724
Commensurate with level of experience

Comprehensive benefits package

Job Description

The laboratory of Douglas Fearon is seeking an outstanding postdoc fellow for research on the interaction between the immune system and pancreatic cancer.

Our laboratory discovered that immune suppression in the tumor microenvironment of an autochthonous model of pancreatic ductal adenocarcinoma is capable of preventing cancer cell-specific CD8+ T cells from controlling tumor growth (Feig, et al, PNAS 2013). Inhibition is mediated by the interaction of the stromal cell-derived chemokine, CXCL12, with its receptor, CXCR4, on T cells prevents them from accumulating in the tumor. We are studying three aspects of this problem: how CXCL12 associates with cancer cells to protect them from immune attack; how this CXCL12 stimulates CXCR4 on T cells to suppress their influx into tumors; and the identification of new CXCR4 antagonists that will overcome this suppressive effect of CXCR4.

We have also developed a new model of pancreatic cancer metastases that has uncovered a remarkable effect of adaptive immunity in establishing occult metastases, the major clinical problem that accounts for the high rate of cancer recurrence following apparently curative surgery. We are testing the possibility that the metabolic changes that accompany pancreatic cancer may lead to activation of these dormant metastatic lesions (Flint, et al. Cell Metab 2016).


Position Requirements:

Successful candidates are expected to stand out through their ongoing original research in the broad areas of molecular, cell or cancer biology. They should either hold or be within a year from obtaining their PhD.

Applicants with an MD degree are also encouraged to apply because the Fearon lab is committed to demonstrating the relevance of pre-clinical research to human disease, and has several collaborations with academic clinical oncology labs.

(Further information can be found at

To be considered, please apply for this position via the CSHL Careers website:

Position Number – 01701-R

CSHL is an EO/AA Employer. All qualified applicants will receive consideration for employment and will not be discriminated against on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability or protected veteran status.

VEVRAA Federal Contractor


How to Apply

o be considered, please apply for this position via the CSHL Careers website

Position Number – 01701-R


About Our Organization

Cold Spring Harbor Laboratory is a world-renowned, private research and education institution with research programs in Cancer, Neuroscience, Plant Biology, Quantitative Biology, and Bioinformatics & Genomics. The research environment is highly collaborative, allowing CSHL scientists to work together across disciplines to solve biology’s most challenging problems. The ultimate goal is to apply this research on basic biological mechanisms to improve the diagnosis and treatment of cancer, neurological disorders and other diseases.

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