Postdoc translational research

Broad Institute
Job Location
Cambridge, MA
Job Description

The Xavier group uses a combination of cell-based assays, novel mouse models, patient samples, and computational analyses to understand the pathogenesis of inflammatory diseases and accelerate their treatment.

We are seeking a highly motivated postdoctoral researcher to join an exciting initiative aimed at identifying small molecules that target the regulatory networks governing gut mucosal immune responses. As a member of our team, the postdoctoral researcher will establish and perform assays aimed at developing and optimizing small molecule probe compounds with the desired characteristics. These probes will then be used

(1) to better understand the mechanisms that modulate gut innate immune responses in health and disease, and

(2) as leads for therapeutics. The role entails working with assay development and high throughput screening scientists, and closely collaborating with a team that includes immunologists, clinicians, computational biologists, and chemists to enable iterative rounds of compound testing and optimization.

- Responsible for the specification, implementation and validation of assays for high-throughput screening.
- Performs detailed characterization of hits and chemically optimized compounds.
- Determines the feasibility and makes recommendations regarding the acquisition and/or implementation of new technologies, reagents and assay procedures.
- Uses demonstrated scientific creativity, collaboration with others and independent thought to expand technical capabilities and identify new research opportunities.

- Ph.D. in immunology, cell biology or biochemistry. Background in autophagy strongly preferred.
- Solid experience in the development of biochemical and/or cell-based assays.
- Experience working with primary cells and mouse disease models a plus.
- Strong publication record and excellent communication skills.
- Excellent organization and time management skills required.
- Must be able to handle a variety of tasks and to adapt to a highly dynamic environment.

EOE/Minorities/Females/Protected Veterans/Disabilities


If interested, please apply online at

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