The Laserson lab is a new lab focused on developing novel high-throughput
technologies for precision immunology. We utilize next-generation sequencing,
synthetic biology, and single-cell methods to build platform technologies.
Application areas include personalized immunotherapy, gut-immune system
interaction, and therapeutic antibody discovery. We are focused on developing
practical tools that others can build on and that will translate clinically.
Uri was born in Tel Aviv and grew up in Miami before studying Math and Biology
during college at NYU. He entered the PhD program in the Math department at
MIT, after which he joined George Church’s lab at Harvard Med to train in
genomics technology development. Uri developed some of the first protocols and
software for next-generation sequencing of the antibody repertoire. He also
collaborated with Ben Larman to help develop the PhIP-seq assay for high-
throughput antigen specificity. During graduate school, Uri cofounded Good
Start Genetics, one of the first diagnostics companies to bring NGS to the
clinic. After earning his PhD, Uri worked at Cloudera, which builds Hadoop
infrastructure for big data. During this time, he became a core member of the
ADAM team developing software for scaling genomics analyses to millions of
samples. In 2016, Uri joined the genetics faculty at Mt Sinai.
You will be a founding member of the lab. Together with the PI, you will be
responsible for defining your research plan and executing it. Research
directions are flexible, but example areas of interest include developing PhIP-
seq-style assays for gut-immune interaction (like IgA-seq), single-cell
phenotyping with NGS, methods for discovering personalized antibody
therapeutics, highly-multiplexed immunohistochemistry. We expect the research
program to require proficiency in a variety of experimental techniques,
including sample/library prep for sequencing, molecular cloning, tissue
culture, antibody assays, and flow cytometry/FACS. Because the lab is new, you
will have the opportunity to help build out a new research lab and will also be
instrumental in defining the lab culture. You can also assist in
training/mentoring graduate students.
And You Are...
We will be utilizing a broad range of cutting-edge techniques, and a
willingness to learn and experiment will be crucial. You should have a PhD or
equivalent experience in a life sciences field. In addition to the techniques
listed above, experience with any of the following would be a plus:
* protein surface display (e.g., phage, yeast, or ribosome display)
* genome editing techniques (e.g., CRISPR)
* synthetic DNA constructs and large oligonucleotide pools
* droplet microfluidics
* single cell methods
* microbiome techniques