Postdoc - Postdoctoral Fellow - Testicular Toxicity Mechanistic Investigation

Job Location
Lake County, IL
Job Description

 AbbVie is a global, research-based biopharmaceutical company formed in 2013 following separation from Abbott Laboratories. The company's mission is to use its expertise, dedicated people and unique approach to innovation to develop and market advanced therapies that address some of the world's most complex and serious diseases. Together with its wholly-owned subsidiary, Pharmacyclics, AbbVie employs more than 28,000 people worldwide and markets medicines in more than 170 countries. 
At AbbVie, our vision is to be recognized as a biopharmaceutical company delivering a consistent stream of innovative medicines that solve serious health issues and have a remarkable impact on people's lives. 
To be successful, we need outstanding individuals willing to challenge themselves to find the best solutions for our patients. The AbbVie Postdoc program is one way we are doing just that. 
Through our Postdoc program, we are hiring postdocs from key academic institutions for preferred areas of science in the U.S., while providing a unique opportunity for participants to build a solid career foundation in the pharmaceutical industry while building the AbbVie brand as an employer of choice for scientific talent. 
The program offers a balance of structured learning and work experience, with accessibility to high-level knowledge building across the drug development continuum to help participants understand how everything fits together and is put into practice. It also provides them with a chance to establish working relationships with some of the world's most respected scientists and leaders in the industry. 
Participants in the Postdoc program play an integral part in our continued success and will help us to further grow as a leader in our industry. 
Key Responsibilities: 
 The candidate will work in a cross-disciplinary team having backgrounds in medicinal chemistry, biochemistry, structural chemistry, chemo- and toxico-informatics, toxicology, pathology, and comparative medicine. The project is limited to a term of 3 years and seeks to increase the prediction of testicular toxicity using in silico , in vitro , imaging (ultrasound), and ex vivo (i.e. biomarker) approaches. These 3 separate approaches will constitute 3 simultaneous work streams and will require the candidate to be familiar with a wide spectrum of methodologies and concepts. The candidate is expected to generate at least one presentation at a national meeting and one publication from each of these efforts. Successful completion of the project should result in a demonstrable increase in accurate prediction and preclinical monitoring of testicular toxicity for at least one mechanism of testicular toxicity. At the completion of the project, the experience and skill set could easily translate to both off- and on-target applications in drug discovery and development



• The candidate should have a wide breadth of knowledge in the fundamental sciences which involve chemical interactions with biological systems including chemical structure and toxicophore identification, data clustering and false discovery rate, xenobiotic disposition and metabolism including transport across membranes, cell signaling pathways, classical mechanisms of pharmacology and toxicity, and basic reproductive anatomy and physiology. The candidate must be able to discern core hypotheses which underpin a body of work and whether supporting data is critical or extraneous. The candidate should have excellent communication skills and demonstrated mastery of the written and spoken word. The candidate should have a record of publications in a well - recognized journals, and should be a graduate of an accredited and nationally ranked university. The candidate should provide a narrative on why your academic training would qualify you for this position and why you have a sustained interest in this program , should provide three letters of recommendation, one at least from your PI, and preferably, one from the Chair of your department or a member of the thesis committee, must be authorized to work in the U.S, should have a proven track record of teamwork, adaptability, innovation, initiative, and integrity, and should have a global mindset to thrive in a diverse culture and environment. ABT board certification desirable. 

• In depth knowledge of reproductive toxicology is beneficial only if it does not come at the expense of breadth of knowledge across other areas. The ideal candidate will have hands on experience with multiple techniques including biochemical, cellular biology, and analytical methods which may be necessary to test hypotheses regarding specific mechanisms of toxicity or the performance of putative biomarkers. The ideal candidate will be familiar with the theory of modern omics technologies such as RNAseq, chromatography, and peptide identification by mass spectrometry. Hands-on experience with the use of informatics software packages or coding ability would be beneficial. The actual candidate may have deficits in one or more areas, but we are seeking candidates with a demonstrated capacity to learn new disciplines and methods. 

• Key Leadership Competencies: 
 • Builds strong relationships with peers and cross functionally with partners outside of the immediate team to enable higher performance 
 • Learns fast, grasps the "essence" and can change course quickly where indicated 
 • Raises the bar and is never satisfied with the status quo 
 • Creates a learning environment, open to suggestions and experimentation to drive the science in the field of interest 
 • Embraces the ideas of others, nurtures innovation and manages innovation to reality fellow 

• For further information on the company and its people, portfolio and commitments, please visit . Follow @abbvie on Twitter or view careers on our Facebook or LinkedIn page. 

• Equal Opportunity Employer Minorities/Women/Veterans/Disabled

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