Postdoc – Molecular Biologist for circulating tumor DNA/RNA profiling at MSKCC

Memorial Sloan Kettering Cancer Center
Job Location
Memorial Sloan Kettering Cancer Center
1275 York Avenue
New York, NY 10065
Job Description

We are looking for a molecular biologist/geneticist to join our team to develop assays for profiling circulating nucleic acids (DNA/RNA) in body fluids (plasma, urine, CSF), or so-called "Liquid Biopsy", of different cancer types, for molecular diagnostics.

lab website:

Our goals: (1) develop molecular assays to profile circulating tumor DNA (ctDNA) or RNA from body fluids and (2) evaluate its utility in different solid cancer types (3) understand their biological characteristics.

We work with a huge range of solid tumor teams and clinical trial teams across MSKCC to address different questions, for example, we collect longitudinal samples and aim to compare ctDNA dynamics with clinical responses to evaluate its informatively on treatment decision.  The possible cancer types include: lung, breast, prostate, kidney, melanoma, brain, pancreas, etc, and we have a particular interest in paediatric cancers.

Our optimal goal is to develop molecular assays that can be implemented in the clinical workflow in a diagnostic laboratory setting.

Description of this role:

The successful candidate will participate in developing methods include targeted deep sequencing, exome sequencing and whole genome sequencing using limited, degraded starting materials.

Prior experience on applying any of these technologies on human tissues (tumor/FFPE) or body fluids (plasma, urine, saliva, CFS) in pregnancy or pathological conditions (not limited to cancer) will be necessary. Understanding of the different molecular strategies for mutation detection and quantification is critical. Basic understanding of cancer genomics will be necessary.

Assay development will be a jointed effort with the Innovation Laboratory of the Center for Molecular Oncology. Clinical evaluation will be done in close collaboration with Diagnostic Molecular Pathology Laboratory and Department of Laboratory Medicine. The ideal candidate will be a team-player with excellent communication and interpersonal skills.



- Master or PhD on molecular biology or related subject

Laboratory techniques:

-       Nucleic acids extraction (DNA/RNA),

-       PCR, digital PCR,

-       DNA quantification,

-       Library preparation (whole-genome / exome / targeted / DNA methylation) for massively parallel sequencing (next-generation sequencing, NGS), or relevant experience.


Statistical knowledge:

Knowledge of biomedical statistics, and experience with statistics programmes such as R, SPSS, Prism, etc.

 Computational techniques:

-       Experience with document-processing programmes such as Microsoft Office (Excel, Word, Powerpoint), etc.

-       Scientific figures management such as Adobe Illustrator, Inkscape, etc. is a plus

-       Experience with programming skill, such as R, Python, MatLab, etc, is a plus.

How to Apply

If you are interested in joining our lab, please submit your curriculum vitae and a cover letter detailing your past research experience, accomplishments, current motivation and future research interests. Include your expected availability date and the names and contact information of three referees to Dana Tsui c/o Yessie Werner at

About Our Organization

Memorial Sloan Kettering Cancer Center offers first-rate research training for postgraduate biomedical scientists and for clinician-scientists who are in the training stages of their careers.

We are committed to helping you gain the experience, skills, and credentials you will need to join a new generation of scientific leaders. In addition to laboratory research training, we offer an extensive career development program to help you achieve your individual goals.

Postdoctoral researchers at Memorial Sloan Kettering work alongside some of the world’s leading scientists. In addition, the Center is home to more than 35 state-of-the art core facilities that foster highly productive research.

More information about postdoctoral fellowship at MSKCC:


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