We are looking for a molecular biologist/geneticist to join our team to develop assays for profiling circulating nucleic acids (DNA/RNA) in body fluids (plasma, urine, CSF), or so-called "Liquid Biopsy", of different cancer types, for molecular diagnostics.
Our goals: (1) develop molecular assays to profile circulating tumor DNA (ctDNA) or RNA from body fluids and (2) evaluate its utility in different solid cancer types (3) understand their biological characteristics.
We work with a huge range of solid tumor teams and clinical trial teams across MSKCC to address different questions, for example, we collect longitudinal samples and aim to compare ctDNA dynamics with clinical responses to evaluate its informatively on treatment decision. The possible cancer types include: lung, breast, prostate, kidney, melanoma, brain, pancreas, etc, and we have a particular interest in paediatric cancers.
Our optimal goal is to develop molecular assays that can be implemented in the clinical workflow in a diagnostic laboratory setting.
Description of this role:
The successful candidate will participate in developing methods include targeted deep sequencing, exome sequencing and whole genome sequencing using limited, degraded starting materials.
Prior experience on applying any of these technologies on human tissues (tumor/FFPE) or body fluids (plasma, urine, saliva, CFS) in pregnancy or pathological conditions (not limited to cancer) will be necessary. Understanding of the different molecular strategies for mutation detection and quantification is critical. Basic understanding of cancer genomics will be necessary.
Assay development will be a jointed effort with the Innovation Laboratory of the Center for Molecular Oncology. Clinical evaluation will be done in close collaboration with Diagnostic Molecular Pathology Laboratory and Department of Laboratory Medicine. The ideal candidate will be a team-player with excellent communication and interpersonal skills.