The autophagic delivery of intracellular pathogens to the lysosome is emerging as a central mechanism of innate and adaptive immunity. The broad objectives of the Xavier lab are to identify new candidate host genes and pathways that contribute to the induction of autophagy (perform genome-wide CRISPR screens, biochemical analysis, and analysis of mutant animals to define target mechanisms), and to develop successful strategies to increase autophagy in cells, thereby leading to new strategies to treat infectious diseases and disorders of mucosal immunity.
Postdoc positions in our group are available to (1) study molecular mechanisms of selective autophagy; (2) determine the role of novel autophagy genes in antibacterial defenses in vivo and identify cell-specific functions of those genes; and (3) identify small molecules that target selective autophagy.
- Ph.D. or M.D./Ph.D. in immunology, cell biology or molecular biology
- Maximum 0-2 years of related postdoc experience preferred
- Well versed in the application of mouse models
- Strong publication record in high-impact journals
If interested, please apply online at http://track.tmpservice.com/ApplyClick.aspx?id=2330830-2647-5321