Postdoc, Autophagy

Broad Institute
Job Location
Cambridge, MA
Job Description

The autophagic delivery of intracellular pathogens to the lysosome is emerging as a central mechanism of innate and adaptive immunity. The broad objectives of the Xavier lab are to identify new candidate host genes and pathways that contribute to the induction of autophagy (perform genome-wide CRISPR screens, biochemical analysis, and analysis of mutant animals to define target mechanisms), and to develop successful strategies to increase autophagy in cells, thereby leading to new strategies to treat infectious diseases and disorders of mucosal immunity.

Postdoc positions in our group are available to (1) study molecular mechanisms of selective autophagy; (2) determine the role of novel autophagy genes in antibacterial defenses in vivo and identify cell-specific functions of those genes; and (3) identify small molecules that target selective autophagy.

- Ph.D. or M.D./Ph.D. in immunology, cell biology or molecular biology
- Maximum 0-2 years of related postdoc experience preferred
- Well versed in the application of mouse models
- Strong publication record in high-impact journals

EOE/Minorities/Females/Protected Veterans/Disabilities

If interested, please apply online at

Students whose classmates are interested in science are more likely to think about a career in science, technology, engineering, and mathematics, a new study says.

CNBC reports that the genetic counseling field is expected to grow as personalized medicine becomes more common.

Gladys Kong writes at Fortune that her STEM background has helped her as a CEO.

Social scientists report that the image of the 'lone scientist' might be deterring US students from STEM careers.