Fred Hutchinson Cancer Research Center, home of three Nobel laureates, is an independent, nonprofit research institution dedicated to the development and advancement of biomedical research to eliminate cancer and other potentially fatal diseases. Recognized internationally for its pioneering work in bone-marrow transplantation, the Center's four scientific divisions collaborate to form a unique environment for conducting basic and applied science. The Hutchinson Center, in collaboration with its clinical and research partners, the University of Washington and Children's Hospital and Regional Medical Center, is the only National Cancer Institute-designated comprehensive cancer center in the Pacific Northwest. Join us and make a difference.
A postdoctoral position is available in the Clurman lab in Clinical Research and Human Biology Divisions at the Fred Hutchinson Cancer Research Center. The Clurman lab's research has focused on the ubiquitin-proteasome system and cell cycle machinery, and their roles in tumorigenesis. This position entails studies of the Fbw7 ubiquitin ligase and the ubiquitin proteasome system in health and disease, and will involve the analyses of transcription factor regulation by Fbw7, biochemical studies of Fbw7 function, the development of murine models of Fbw7-associated cancer, and therapeutic Fbw7 targeting (Davis, Welcker, and Clurman. 2014, Cancer Cell). Applications from individuals with a strong interest in cancer biology and who can work creatively and independently are encouraged.
Essential Skills and Requirements:
Candidates should be highly motivated individuals with a recent Ph.D. and/or M.D. and a strong background and skillset in molecular and cell biology. Experience in Chip-Seq methods and analyses, as well as murine cancer models, is also highly desirable.
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