Post-Doctoral Research Fellow, Tumor Cell Clusters and Metastasis

Fred Hutchinson Cancer Research Center & Seattle Cancer Care Alliance
Job Location
Seattle, WA
Job Description

Cures Start Here.
At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch's pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer with minimal side effects. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation's first and largest cancer prevention research program, as well as the clinical coordinating center of the Women's Health Initiative and the international headquarters of the HIV Vaccine Trials Network.

Careers Start Here.
A highly motivated post-doctoral research fellow is sought to carry out a research project in the field of cancer biology focusing on the mechanisms by which tumor cell clusters metastasize to distant organs. This position is in the laboratory of Dr. Kevin Cheung at the Fred Hutchinson Cancer Research Center in Seattle, WA. Recent graduate students at the end of their training program who are eligible to participate in NIH-funded training grants and fellowships are especially encouraged to apply.

About our laboratory:
Our research program originates from the intriguing clinical observation that at every stage of metastasis cancer cells are found to travel as clusters ( This is clinically important because the presence of clusters in the local vasculature and in the systemic circulation is associated with significantly worse patient outcomes. Yet many questions remain unanswered about why tumor cells travel as groups or how they reach and colonize distant sites. Work in our laboratory focuses on uncovering the collective cell behaviors that emerge during the metastasis of these clusters (Cheung et al. Cell 2013; Cheung et al. PNAS 2016). Our studies have identified specialized 'leader cells' that lead collective invasion and dissemination. We have developed models to study the interactions and cell dynamics of tumor cell clusters using 'tumor organoids' and primary tumor specimens from patients. The ultimate mission of our laboratory is to leverage our understanding of tumor cell clusters to inform new ways to prevent and treat breast cancer metastases.

The position will focus on spearheading one of several core projects in our laboratory, and contributing scientifically as a valued member of our research group.

To be considered, candidates must have:
- A recent PhD in a relevant biological field
- A strong background in molecular and cell biology techniques
- A demonstrated track record of productive research, and at least two first author publications
- Experience with murine cancer models and microscopy is highly desirable
- An ability to work both independently and as part of a laboratory team

Pay, Benefits, & Work Schedule:
Full time position
Salary DOE + excellent benefits

To Apply:
Please apply with a letter summarizing previous work experience, suitability for this position and future research interests, as well as contact information for three professional references.

To apply for this position, please CLICK HERE

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