Fred Hutchinson Cancer Research Center, home of three Nobel laureates, is an independent, nonprofit research institution dedicated to the development and advancement of biomedical research to eliminate cancer and other potentially fatal diseases. Recognized internationally for its pioneering work in bone-marrow transplantation, the Center's four scientific divisions collaborate to form a unique environment for conducting basic and applied science. The Hutchinson Center, in collaboration with its clinical and research partners, the University of Washington and Children's Hospital and Regional Medical Center, is the only National Cancer Institute-designated comprehensive cancer center in the Pacific Northwest. Join us and make a difference.
A postdoctoral position is available in the Clurman lab in Clinical Research and Human Biology Divisions at the Fred Hutchinson Cancer Research Center. The Clurman lab's research has focused on the ubiquitin-proteasome system and cell cycle machinery, and their roles in tumorigenesis. This position entails studies of cyclin-dependent kinase 2 (CDK2) regulation and function in DNA replication, DNA damage and replication stress, and carcinogenesis, including therapeutic targeting of CDK2 in cancer therapy. This work will utilize a range of approaches, including gene targeting in human cells and mice, mouse models of CDK2-driven cancer, and biochemical studies of CDK2 regulation and substrates. Applications from individuals with a strong interest in cancer biology and who can work creatively and independently are encouraged.
Essential Skills and Requirements: Candidates should be highly motivated individuals with a recent Ph.D. and/or M.D. and a strong background and skillset in molecular and cell biology. Experience in murine cancer models and the analysis of histone modifications is also highly desirable.
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